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Opsoclonus-myoclonus-ataxia syndrome associated with chikungunya and dengue virus co-infection

机译:基孔肯雅热与登革热病毒合并感染相关的视神经-肌阵挛-共济失调综合征

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Opsoclonus-myoclonus-ataxia syndrome (OMAS) is a rare neurological disorder characterized by irregular multidirectional eye movements, myoclonus, cerebellar ataxia, sleep disturbances, and cognitive dysfunction. Although most commonly related to paraneoplastic syndrome, this condition has occasionally been described following infectious illnesses. This article reports the first case of OMAS in association with chikungunya and dengue virus co-infection. The genetic analysis identified chikungunya virus of East/Central/South African genotype and dengue serotype 4 virus of genotype II. This report represents an unusual clinical syndrome associated with viral co-infection and reinforces the need for clinical vigilance with regard to neurological syndromes in the context of emergent arboviruses.
机译:肌阵挛-肌阵挛-共济失调综合征(OMAS)是一种罕见的神经系统疾病,其特征在于不规则的多向眼球运动,肌阵挛,小脑共济失调,睡眠障碍和认知功能障碍。尽管最常见与副肿瘤综合症相关,但在感染性疾病后偶尔会描述这种情况。本文报道了第一例与基孔肯雅热和登革热病毒共同感染有关的OMAS。遗传分析确定了东/中/南非基因型的基孔肯雅病毒和基因型II的登革热血清型4病毒。该报告代表了与病毒共感染相关的一种不寻常的临床综合征,并加强了在紧急虫媒病毒情况下对神经系统综合征进行临床警惕的需要。

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