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首页> 外文期刊>International Journal of Molecular Sciences >Identification of Plasma Metabolomic Profiling for Diagnosis of Esophageal Squamous-Cell Carcinoma Using an UPLC/TOF/MS Platform
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Identification of Plasma Metabolomic Profiling for Diagnosis of Esophageal Squamous-Cell Carcinoma Using an UPLC/TOF/MS Platform

机译：使用UPLC / TOF / MS平台鉴定血浆代谢组学谱用于诊断食管鳞状细胞癌

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Epidemiological studies indicated that esophageal squamous-cell carcinoma (ESCC) is still one of the most common causes of cancer incidence in the world. Searching for valuable markers including circulating endogenous metabolites associated with the risk of esophageal cancer, is extremely important A comparative metabolomics study was performed by using ultraperformance liquid chromatography-electrospray ionization-accurate mass time-of-flight mass spectrometry to analyze 53 pairs of plasma samples from ESCC patients and healthy controls recruited in Huaian, China. The result identified a metabolomic profiling of plasma including 25 upregulated metabolites and five downregulated metabolites, for early diagnosis of ESCC. With a database-based verification protocol, 11 molecules were identified, and six upregulated molecules of interest in ESCC were found to belong to phospholipids as follows: phosphatidylserine, phosphatidic acid, phosphatidyl choline, phosphatidylinositol, phosphatidyl ethanolamine, and sphinganine 1-phosphate. Clinical estimation of metabolic biomarkers through hierarchical cluster analysis in plasma samples from 17 ESCC patients and 29 healthy volunteers indicated that the present metabolite profile could distinguish ESCC patients from healthy individuals. The cluster of aberrant expression of these metabolites in ESCC indicates the critical role of phospholipid metabolism in the oncogenesis of ESCC and suggests its potential ability to assess the risk of ESCC development in addition to currently used risk factors.
机译：流行病学研究表明，食管鳞状细胞癌（ESCC）仍然是世界上最常见的癌症发病原因之一。寻找有价值的标志物，包括与食管癌风险相关的循环内源性代谢物，非常重要。通过使用超高效液相色谱-电喷雾电离-精确质量飞行时间质谱分析53对血浆样品，进行了比较代谢组学研究来自中国淮安市的ESCC患者和健康对照者。该结果确定了血浆的代谢组学谱，包括25种上调的代谢物和5种下调的代谢物，用于ESCC的早期诊断。使用基于数据库的验证协议，鉴定了11个分子，发现ESCC中有6个上调的目标分子属于以下磷脂：磷脂酰丝氨酸，磷脂酸，磷脂酰胆碱，磷脂酰肌醇，磷脂酰乙醇胺和鞘氨醇1-磷酸。通过分层聚类分析对来自17位ESCC患者和29位健康志愿者的血浆样品进行代谢生物标记物的临床评估表明，目前的代谢物特征可以将ESCC患者与健康个体区分开。这些代谢产物在ESCC中异常表达的簇表明，磷脂代谢在ESCC的肿瘤发生中起着关键作用，并暗示了其除当前使用的危险因素外，还具有评估ESCC发生风险的潜在能力。

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