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首页> 外文期刊>International Journal of Molecular Sciences >miRNAs Regulation and Its Role as Biomarkers in Endometriosis
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miRNAs Regulation and Its Role as Biomarkers in Endometriosis

机译：miRNA调控及其在子宫内膜异位症中作为生物标志物的作用

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MicroRNAs (miRNAs) are small non-coding RNAs (18–22 nt) that function as modulators of gene expression. Since their discovery in 1993 in C. elegans, our knowledge about their biogenesis, function, and mechanism of action has increased enormously, especially in recent years, with the development of deep-sequencing technologies. New biogenesis pathways and sources of miRNAs are changing our concept about these molecules. The study of the miRNA contribution to pathological states is a field of great interest in research. Different groups have reported the implication of miRNAs in pathologies such as cancer, diabetes, cardiovascular, and gynecological diseases. It is also well-known that miRNAs are present in biofluids (plasma, serum, urine, semen, and menstrual blood) and have been proposed as ideal candidates as disease biomarkers. The goal of this review is to highlight the current knowledge in the field of miRNAs with a special emphasis to their role in endometriosis and the newest investigations addressing the use of miRNAs as biomarkers for this gynecological disease.
机译：MicroRNA（miRNA）是小的非编码RNA（18-22 nt），可作为基因表达的调节剂。自从1993年在秀丽隐杆线虫中发现它们以来，我们对它们的生物发生，功能和作用机理的了解已大大增加，尤其是近年来，随着深度测序技术的发展。 miRNA的新生物发生途径和来源正在改变我们对这些分子的观念。 miRNA对病理状态的贡献的研究是研究中非常感兴趣的领域。不同的研究小组报告了miRNA在诸如癌症，糖尿病，心血管和妇科疾病等病理学中的意义。众所周知，miRNA存在于生物流体（血浆，血清，尿液，精液和经血）中，并已被提议作为疾病生物标记物的理想候选者。这篇综述的目的是突出miRNA领域的当前知识，特别强调它们在子宫内膜异位症中的作用，以及有关使用miRNA作为该妇科疾病生物标志物的最新研究。

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