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首页> 外文期刊>International Journal of Molecular Sciences >Antioxidant Activity of γ-Oryzanol: A Complex Network of Interactions
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Antioxidant Activity of γ-Oryzanol: A Complex Network of Interactions

机译：γ-谷维素的抗氧化活性：复杂的相互作用网络。

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摘要

γ-oryzanol (Orz), a steryl ferulate extracted from rice bran layer, exerts a wide spectrum of biological activities. In addition to its antioxidant activity, Orz is often associated with cholesterol-lowering, anti-inflammatory, anti-cancer and anti-diabetic effects. In recent years, the usefulness of Orz has been studied for the treatment of metabolic diseases, as it acts to ameliorate insulin activity, cholesterol metabolism, and associated chronic inflammation. Previous studies have shown the direct action of Orz when downregulating the expression of genes that encode proteins related to adiposity (CCAAT/enhancer binding proteins (C/EBPs)), inflammatory responses (nuclear factor kappa-B (NF-κB)), and metabolic syndrome (peroxisome proliferator-activated receptors (PPARs)). It is likely that this wide range of beneficial activities results from a complex network of interactions and signals triggered, and/or inhibited by its antioxidant properties. This review focuses on the significance of Orz in metabolic disorders, which feature remarkable oxidative imbalance, such as impaired glucose metabolism, obesity, and inflammation.
机译：γ-谷维素（Orz）是一种从米糠层提取的甾烷阿魏酸酯，具有广泛的生物活性。除了具有抗氧化作用外，Orz还经常与降低胆固醇，消炎，抗癌和抗糖尿病作用相关。近年来，已经研究了Orz在治疗代谢性疾病中的作用，因为它可改善胰岛素活性，胆固醇代谢和相关的慢性炎症。先前的研究表明，Orz在下调编码与肥胖相关的蛋白质（CCAAT /增强子结合蛋白（C / EBPs）），炎症反应（核因子κB（NF-κB））的基因表达时的直接作用。代谢综合征（过氧化物酶体增殖物激活受体（PPAR））。如此广泛的有益活动可能是由于相互作用和信号的复杂网络所致，这些相互作用和信号被其抗氧化剂特性触发和/或抑制。这篇综述着重于Orz在代谢异常中的重要性，该异常具有明显的氧化失衡，例如葡萄糖代谢受损，肥胖和发炎。

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