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Diabetes-related tuberculosis in the Middle East: an urgent need for regional research

机译:中东与糖尿病有关的结核病:急需进行区域研究

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Objectives: Diabetes mellitus (DM) triples the risk of tuberculosis (TB) disease, complicates TB treatment, and increases the risk of a poor TB outcome. As DM prevalence is increasing across the Middle East, this review was performed to identify regional gaps in knowledge and research priorities for DM/TB. Methods: Online databases were searched for studies published from Middle East countries on DM and TB and the studies summarized based on topic and major findings. Studies included had a principle hypothesis related to both diseases, or described TB patients with individual data on DM. Results: Fifty-nine studies from 10 countries met search criteria. No published studies were found from Lebanon, Bahrain, Syria, Jordan, Cyprus, or the United Arab Emirates. DM prevalence among TB patients was high, but varied considerably across studies. The vast majority of studies were not specifically designed to compare DM/TB and non-DM/TB patients, but many suggested worse treatment outcomes for DM/TB, in accordance with reports from other regions. Conclusions: Opportunity exists for the regional study of bidirectional screening, management strategies for both DM and TB diseases, and whether such efforts could take place through the integration of services.
机译:目的:糖尿病(DM)使结核病(TB)的风险增加三倍,使结核病治疗复杂化,并增加不良结核病结局的风险。随着整个中东地区DM患病率的上升,进行了此项审查以查明DM / TB知识和研究重点的区域差距。方法:在在线数据库中搜索中东国家发表的有关糖尿病和结核病的研究,并根据主题和主要发现对研究进行总结。所包括的研究具有与两种疾病相关的原理假设,或描述了具有DM个体数据的TB患者。结果:来自10个国家的59个研究符合搜索标准。黎巴嫩,巴林,叙利亚,约旦,塞浦路斯或阿拉伯联合酋长国未发现已发表的研究。结核病患者中糖尿病的患病率很高,但各研究之间差异很大。根据其他地区的报告,绝大多数研究并非专门设计用于比较DM / TB和非DM / TB患者,但是许多研究表明DM / TB的治疗效果较差。结论:双向筛查,DM和TB疾病的管理策略以及是否可以通过整合服务来开展此类工作的区域研究存在机会。

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