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首页> 外文期刊>International journal of infectious diseases : >The impact of Clostridium difficile infection on resource use and costs in hospitals in Spain and Italy: a matched cohort study
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The impact of Clostridium difficile infection on resource use and costs in hospitals in Spain and Italy: a matched cohort study

机译：匹配队列研究：难辨梭状芽胞杆菌感染对西班牙和意大利医院的资源使用和成本的影响

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Objective: To assess the impact of Clostridium difficile infection (CDI) on hospital resources and costs in Spain and Italy. Methods: CDI data were collected from institutions in Spain and Italy. Each patient was matched with two randomly selected uninfected controls in the same institution. Patient outcomes were assessed for the first and second episodes of CDI and for patients aged @?65 and >65 years. The impact of CDI on hospital length of stay (LOS) was used to calculate CDI-attributable costs. A multivariate analysis using duration of stay as the continuous outcome variable assessed the independent effect of CDI on hospital costs and LOS. Results: LOS attributable to CDI ranged from 7.6-19.0 days in adults and was 5.0 days in children; the increases were greater in adults in Italy than in Spain. Attributable costs per adult patient ranged from @?4396 in Madrid to @?14 023 in Rome, with the majority of the cost being due to hospitalization. For children, the total attributable cost was @?3545/patient. Conclusions: These data show that the burden of CDI is considerable in Spain and Italy. Treatments that can reduce LOS, disease severity, and recurrence rates, as well as effective infection control measures to prevent transmission, have the potential to reduce the burden of CDI.
机译：目的：评估艰难梭菌感染（CDI）对西班牙和意大利医院资源和成本的影响。方法：从西班牙和意大利的机构收集CDI数据。每个患者都与同一机构中两个随机选择的未感染对照相匹配。对CDI的第一和第二次发作以及65岁及65岁以上的患者评估了患者的预后。 CDI对医院住院时间（LOS）的影响用于计算CDI归因成本。使用住院时间作为连续结果变量的多变量分析评估了CDI对医院费用和LOS的独立影响。结果：归因于CDI的LOS在成人中为7.6-19.0天，儿童为5.0天。意大利成人的增加幅度大于西班牙。每名成年患者的归属费用从马德里的4396欧元到罗马的1420欧元不等，其中大部分费用是由于住院治疗。对于儿童，总归因成本为每位患者3545英镑。结论：这些数据表明，西班牙和意大利的CDI负担相当大。可以降低LOS，疾病严重程度和复发率的治疗方法，以及可以防止传染的有效感染控制措施，都有可能减轻CDI负担。

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