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首页> 外文期刊>International journal of infectious diseases : >Dynamics of immune parameters during the treatment of active tuberculosis showing negative interferon gamma response at the time of diagnosis
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Dynamics of immune parameters during the treatment of active tuberculosis showing negative interferon gamma response at the time of diagnosis

机译：诊断为活动性结核病期间免疫参数的动态变化，显示干扰素γ应答为阴性

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Objectives: In the performance of interferon gamma release assays (IGRA) for the diagnosis of tuberculosis (TB) infection, false-negative results are a major obstacle. In active TB patients, treatment-dependent changes of the negative test results remain unknown. Methods: The treatment course of 19 smear-positive/culture-confirmed TB patients who had IGRA-negative results by QuantiFERON-TB in-tube (QFT-IT) method at the time of diagnosis (month 0) in a previous study, were monitored in the present study. Blood was further collected at months 2 and 7, and the concentrations of 27 immune molecules were measured in the plasma supernatants remaining after performing the IGRA, using a suspension array system. Results: After initiating treatment, eight of the 19 QFT-IT-negative patients showed positive conversion, whereas the remaining 11 (58%) did not; the interferon gamma (IFN-@c) response was restored to levels higher than 1 IU/ml in only three of the eight patients with positive conversion. Plasma concentrations of interleukin 1 receptor antagonist, interleukin 2, and interferon gamma-induced protein 10 remained low after Mycobacterium tuberculosis-specific antigen stimulation at months 2 and 7 in the continuously QFT-IT-negative group, whereas the parameters were elevated only in the transiently QFT-IT-negative group. Conclusions: It was demonstrated that a majority of active TB patients showing negative IGRA results did not regain sufficient levels of immune responsiveness despite successful treatment.
机译：目的：在进行干扰素γ释放分析（IGRA）诊断结核（TB）感染的过程中，假阴性结果是主要障碍。在活动性结核患者中，阴性测试结果的治疗依赖性变化仍然未知。方法：在先前的研究中，对诊断为诊断时（第0个月）通过QuantiFERON-TB管内（QFT-IT）方法进行IGRA阴性的19例涂片阳性/经培养证实的结核病患者的治疗过程为在本研究中进行监测。在第2和第7个月进一步收集血液，并使用悬浮阵列系统在执行IGRA后测量剩余的血浆上清液中27种免疫分子的浓度。结果：在开始治疗后，19例QFT-IT阴性患者中有8例表现为阳性转化，而其余11例（58％）没有阳性转化。八位转化阳性的患者中只有三位将干扰素γ（IFN-c）反应恢复到高于1 IU / ml的水平。在连续QFT-IT阴性组的结核分枝杆菌特异性抗原刺激后第2和第7个月，白细胞介素1受体拮抗剂，白介素2和干扰素γ诱导的蛋白10的血浆浓度仍然较低。瞬态QFT-IT阴性组。结论：已证明，尽管治疗成功，但大多数表现出IGRA阴性的活动性结核病患者仍未获得足够水平的免疫应答。

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