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首页> 外文期刊>International journal of infectious diseases : >Severe bacterial infections in patients with non-transfusion-dependent thalassemia: prevalence and clinical risk factors
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Severe bacterial infections in patients with non-transfusion-dependent thalassemia: prevalence and clinical risk factors

机译：非输血性地中海贫血患者的严重细菌感染：患病率和临床危险因素

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Introduction: Bacterial infection is one of the major causes of death in patients with thalassemia. Clinical predictive factors for severe bacterial infection were evaluated in patients with non-transfusion-dependent thalassemia (NTDT). Methods: A retrospective study was conducted of patients with NTDT aged >=10 years at Srinagarind Hospital, Khon Kaen University, Thailand. Clinical characteristics and potential clinical risk factors for bacterial infection were collected. Risk factors for bacterial infection were evaluated by multivariate logistic regression analysis. Results: A severe bacterial infection was found in 11 of the total 211 patients with NTDT (5.2%). None of the clinical factors assessed was shown to be statistically associated with severe bacterial infection in patients with NTDT. However, three factors were demonstrated to be potential predictive factors for severe bacterial infection: time after splenectomy >10 years, deferoxamine therapy, and serum ferritin >1000 ng/ml. None of the patients died from infection. Conclusion: The prevalence of bacterial infection in patients with NTDT was found to be moderate. Time after splenectomy >10 years, deferoxamine therapy, and iron overload may be clinical risk factors for severe bacterial infection in patients with NTDT. Bacterial infection should be recognized in splenectomized patients with NTDT, particularly those who have an iron overload.
机译：简介：细菌感染是地中海贫血患者的主要死亡原因之一。在非输血依赖型地中海贫血（NTDT）患者中评估了严重细菌感染的临床预测因素。方法：回顾性研究在泰国孔敬大学Srinagarind医院对≥10岁的NTDT患者进行。收集细菌感染的临床特征和潜在的临床危险因素。通过多元逻辑回归分析评估细菌感染的危险因素。结果：在211例NTDT患者中，有11例发现严重细菌感染（5.2％）。在NTDT患者中，评估的临床因素均未显示与严重细菌感染相关。但是，已证明三个因素是严重细菌感染的潜在预测因素：脾切除后的时间> 10年，去铁胺治疗和血清铁蛋白> 1000 ng / ml。没有病人死于感染。结论：NTDT患者的细菌感染患病率为中等。脾切除后的时间> 10年，去铁胺治疗和铁超负荷可能是NTDT患者严重细菌感染的临床危险因素。 NTDT脾切除术的患者，尤其是铁超负荷的患者，应认识到细菌感染。

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