Synthetic Efforts for Stereo Structure Determination of Cytotoxic Marine Natural Product Pericosines as Metabolites of Periconia sp. from Sea Hare

Yoshihide Usami

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Synthetic Efforts for Stereo Structure Determination of Cytotoxic Marine Natural Product Pericosines as Metabolites of Periconia sp. from Sea Hare

机译：合成努力立体结构测定细胞毒性海洋天然产物Pericosines作为Periconia sp。的代谢产物。从海兔

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Pericosines are unique C₇ cyclohexenoid metabolites of Periconia byssoides OUPS-N133 fungus that was originally isolated from the sea hare, Aplysia kurodai. Pericosines show significant in vitro cytotoxicity against P388 lymphocytic leukemia cells. Pericosine A, in particular, shows the most potent activity and significant in vivo antitumor activity against P388 cells. Thus, pericosines are promising candidates for seed compounds of anticancer drugs. However, before the total syntheses of pericosines were accomplished, their stereo structures could not be determined by spectral analyses because they have multi-functionalized cyclohexenoid structures with torsional strain. In this review, synthetic efforts for pericosines in this decade are surveyed.

机译：Pericosines是Periconia byssoides OUPS-N133真菌的独特C _{7 环己烯类代谢产物，最初是从海兔Aplysia kurodai中分离出来的。 Pericosines对P388淋巴细胞白血病细胞显示出显着的体外细胞毒性。特别是，Pericosine A对P388细胞显示出最有效的活性和显着的体内抗肿瘤活性。因此，percosines是抗癌药种子化合物的有希望的候选者。但是，在完成全部皮囊壁蛋白的合成之前，无法通过光谱分析确定其立体结构，因为它们具有带有扭转应变的多功能环己烯结构。在这篇综述中，调查了近十年来人们对皮氨酸的综合研究。}

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《International Journal of Molecular Sciences》 |2008年第3期|共21页
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Yoshihide Usami;
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中图分类生物物理学;
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1. First Total Synthesis of Antitumor Natural Product (+)- and (-)-Pericosine A: Determination of Absolute Stereo Structure [J] . Yoshihide Usami, Isao Takaoka, Hayato Ichikawa, The Journal of Organic Chemistry . 2007,第16期

机译：首次全合成抗肿瘤天然产物（+）-和（-）-Pericosine A：绝对立体结构的测定
2. First Total Synthesis of Antitumor Natural Product (+)- and (—)-Pericosine A: Determination of Absolute Stereo Structure [J] . Yoshihide Usami, Isao Takaoka, Hayato Ichikawa, The Journal of Organic Chemistry . 2007,第16期

机译：首次全合成抗肿瘤天然产物（+）-和（-）-Pericosine A：绝对立体结构的测定
3. Pericosines, antitumour metabolites from the sea hare-derived fungus Peviconia byssoides. Structures and biological activities [J] . Takeshi Yamada, Masashi Iritani, Hirohumi Ohishi, Organic & biomolecular chemistry . 2007,第24期

机译：Pericosines，来自海兔的真菌Peviconia byssoides的抗肿瘤代谢产物。结构与生物活性
4. Cytotoxic Studies of Natural Product Derivatives for Therapeutic In Vivo Synthetic Chemistry [C] . Peni Ahmadi, Shohei Eda, Katsunori Tanaka 日本化学会春季年会講演予稿集 . 2018

机译：体内合成化学治疗天然产物衍生物的细胞毒性研究
5. I. Identification and structure elucidation of cytotoxic chamigrenes from the red alga Laurencia sp. II. Synthetic studies toward the sponge metabolite salicylihalamide A. [D] . Francisco, Maria Elena Yalong. 2000

机译：I.红藻劳伦西亚菌的细胞毒性变态毒素的鉴定和结构阐明。二。对海绵代谢产物水杨卤代酰胺A的合成研究。
6. Synthetic Efforts for Stereo Structure Determination of Cytotoxic Marine Natural Product Pericosines as Metabolites of Periconia sp. from Sea Hare [O] . Yoshihide Usami, Hayato Ichikawa, Masao Arimoto 2008

机译：合成努力立体结构测定的细胞毒性海洋天然产物Pericosines作为Periconia sp。的代谢产物。从海兔
7. Synthetic Efforts for Stereo Structure Determination of Cytotoxic Marine Natural Product Pericosines as Metabolites of Periconia sp. from Sea Hare [O] . Usami, Yoshihide, Ichikawa, Hayato, Arimoto, Masao 2008

机译：合成努力立体结构测定的细胞毒性海洋天然产物Pericosines作为Periconia sp。的代谢产物。从海兔
8. Some Structures of Marine Natural Products [R] . Finer-Moore, J. S. 1979

机译：海洋天然产物的一些结构

Synthetic Efforts for Stereo Structure Determination of Cytotoxic Marine Natural Product Pericosines as Metabolites of Periconia sp. from Sea Hare

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