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首页> 外文期刊>International Journal of Molecular Sciences >TM4SF1 Promotes Proliferation, Invasion, and Metastasis in Human Liver Cancer Cells
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TM4SF1 Promotes Proliferation, Invasion, and Metastasis in Human Liver Cancer Cells

机译：TM4SF1促进人肝癌细胞的增殖，侵袭和转移

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摘要

Transmembrane 4 superfamily member 1 ( TM4SF1 ) is a member of tetraspanin family, which mediates signal transduction events regulating cell development, activation, growth and motility. Our previous studies showed that TM4SF1 is highly expressed in liver cancer. HepG2 cells were transfected with TM4SFl siRNA and TM4SF1 -expressing plasmids and their biological functions were analyzed in vitro and in vivo . HepG2 cells overexpressing TM4SF1 showed reduced apoptosis and increased cell migration in vitro and enhanced tumor growth and metastasis in vivo , whereas siRNA-mediated silencing of TM4SF1 had the opposite effect. TM4SF1 exerts its effect by regulating a few apoptosis- and migration-related genes including caspase-3 , caspase-9 , MMP-2 , MMP-9 and VEGF . These results indicate that TM4SF1 is associated with liver tumor growth and progression, suggesting that TM4SF1 may be a potential target for treatment of liver cancer in future.
机译：跨膜4超家族成员1（TM4SF1）是四跨素家族的成员，其介导调节细胞发育，活化，生长和运动的信号转导事件。我们以前的研究表明TM4SF1在肝癌中高表达。用TM4SF1 siRNA和表达TM4SF1的质粒转染HepG2细胞，并在体内和体外分析其生物学功能。过度表达TM4SF1的HepG2细胞在体外显示出减少的凋亡和增加的细胞迁移，并在体内增强了肿瘤的生长和转移，而siRNA介导的TM4SF1沉默则相反。 TM4SF1通过调节一些与凋亡和迁移相关的基因发挥作用，包括caspase-3，caspase-9，MMP-2，MMP-9和VEGF。这些结果表明TM4SF1与肝肿瘤的生长和进展有关，提示TM4SF1可能是将来治疗肝癌的潜在靶标。

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