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首页> 外文期刊>International Journal of Molecular Sciences >Memantine Attenuates Delayed Vasospasm after Experimental Subarachnoid Hemorrhage via Modulating Endothelial Nitric Oxide Synthase
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Memantine Attenuates Delayed Vasospasm after Experimental Subarachnoid Hemorrhage via Modulating Endothelial Nitric Oxide Synthase

机译：美金刚通过调节内皮型一氧化氮合酶减轻实验性蛛网膜下腔出血后延迟的血管痉挛

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摘要

Delayed cerebral vasospasm is an important pathological feature of subarachnoid hemorrhage (SAH). The cause of vasospasm is multifactorial. Impairs nitric oxide availability and endothelial nitric oxide synthase (eNOS) dysfunction has been reported to underlie vasospasm. Memantine, a low-affinity uncompetitive N-methyl-d-aspartate (NMDA) blocker has been proven to reduce early brain injury after SAH. This study investigated the effect of memantine on attenuation of vasospasm and restoring eNOS functionality. Male Sprague-Dawley rats weighing 350–450 g were randomly divided into three weight-matched groups, sham surgery, SAH + vehicle, and SAH + memantine groups. The effects of memantine on SAH were evaluated by assessing the severity of vasospasm and the expression of eNOS. Memantine effectively ameliorated cerebral vasospasm by restoring eNOS functionality. Memantine can prevent vasospasm in experimental SAH. Treatment strategies may help combat SAH-induced vasospasm in the future.
机译：延迟性脑血管痉挛是蛛网膜下腔出血（SAH）的重要病理特征。血管痉挛的原因是多因素的。据报道，一氧化氮的可用性受损和内皮型一氧化氮合酶（eNOS）功能障碍是血管痉挛的基础。美金刚胺是一种低亲和力的非竞争性N-甲基-d-天冬氨酸（NMDA）阻滞剂，已被证明可以减少SAH后早期的脑损伤。这项研究调查了美金刚对血管痉挛衰减和恢复eNOS功能的影响。将体重350–450 g的雄性Sprague-Dawley大鼠随机分为三组，分别为体重匹配组，假手术组，SAH +载体和SAH +美金刚组。通过评估血管痉挛的严重程度和eNOS的表达来评估美金刚对SAH的作用。美金刚通过恢复eNOS功能有效地改善了脑血管痉挛。美金刚可以预防实验性SAH中的血管痉挛。未来的治疗策略可能有助于对抗SAH引起的血管痉挛。

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