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首页> 外文期刊>International Journal of Molecular Sciences >Exploration of the Protection of Riboflavin Laurate on Oral Mucositis Induced by Chemotherapy or Radiotherapy at the Cellular Level: What Is the Leading Contributor?
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Exploration of the Protection of Riboflavin Laurate on Oral Mucositis Induced by Chemotherapy or Radiotherapy at the Cellular Level: What Is the Leading Contributor?

机译:在细胞水平上探讨月桂酸核黄素对化学疗法或放射疗法诱导的口腔粘膜炎的保护作用:主要作用是什么?

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Oral or gastrointestinal mucositis is a frequent phenomenon in cancer patients receiving chemotherapy or radiotherapy. In addition, several clinical investigations have demonstrated in recent years that riboflavin laurate has the potential to protect the patients from the disease induced by chemotherapy or radiotherapy. In our studies, it is observed that riboflavin laurate can ameliorate either chemotherapy- or radiotherapy-induced toxicities on Helf cells, and the effect is greater than that of riboflavin. In addition, riboflavin laurate is able to transport through the Caco-2 cell monolayer as the prototype, indicating the protective effects may be produced by the prototype of riboflavin laurate, rather than simply by the released riboflavin.
机译:在接受化学疗法或放射疗法的癌症患者中,口腔或胃肠道粘膜炎是常见现象。另外,近年来的一些临床研究表明,月桂核黄素具有保护患者免受化学疗法或放射疗法诱发的疾病的潜力。在我们的研究中,观察到月桂酸核黄素可以改善化疗或放疗诱导的对Helf细胞的毒性,其作用要大于核黄素。此外,月桂核黄素能够作为原型通过Caco-2细胞单层运输,这表明保护作用可能是由月桂核黄素的原型产生的,而不是简单地由释放的核黄素产生的。

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