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Retinal Cell Degeneration in Animal Models

机译:动物模型中的视网膜细胞变性

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The aim of this review is to provide an overview of various retinal cell degeneration models in animal induced by chemicals ( N -methyl- d -aspartate- and CoCl 2 -induced), autoimmune (experimental autoimmune encephalomyelitis), mechanical stress (optic nerve crush-induced, light-induced) and ischemia (transient retinal ischemia-induced). The target regions, pathology and proposed mechanism of each model are described in a comparative fashion. Animal models of retinal cell degeneration provide insight into the underlying mechanisms of the disease, and will facilitate the development of novel effective therapeutic drugs to treat retinal cell damage.
机译:这篇综述的目的是概述由化学物质(N-甲基-d-天门冬氨酸和CoCl 2诱导),自身免疫(实验性自身免疫性脑脊髓炎),机械应激(视神经挤压)诱导的各种视网膜细胞变性模型-诱导,光诱导)和局部缺血(短暂性视网膜缺血-诱导)。以比较的方式描述了每个模型的目标区域,病理学和提出的机制。视网膜细胞变性的动物模型提供了对该疾病潜在机制的洞察力,并将促进开发新型有效的治疗药物来治疗视网膜细胞损伤。

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