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首页> 外文期刊>International Journal of Molecular Sciences >The Clinical Significance of Phosphorylated Heat Shock Protein 27 (HSPB1) in Pancreatic Cancer
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The Clinical Significance of Phosphorylated Heat Shock Protein 27 (HSPB1) in Pancreatic Cancer

机译：磷酸化热休克蛋白27（HSPB1）在胰腺癌中的临床意义

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摘要

Pancreatic cancer is one of most aggressive forms of cancer. After clinical detection it exhibits fast metastatic growth. Heat shock protein 27 (HSP27; HSPB1) has been characterized as a molecular chaperone which modifies the structures and functions of other proteins in cells when they are exposed to various stresses, such as chemotherapy. While the administration of gemcitabine, an anti-tumor drug, has been the standard treatment for patients with advanced pancreatic cancer, accumulating evidence shows that HSP27 plays a key role in the chemosensitivity to gemcitabine. In addition, phosphorylated HSP27 induced by gemcitabine has been associated with the inhibition of pancreatic cancer cell growth. In this review, we summarize the role of phosphorylated HSP27, as well as HSP27, in the regulation of chemosensitivity in pancreatic cancer.
机译：胰腺癌是最积极的癌症形式之一。临床检测后，它表现出快速的转移性生长。热休克蛋白27（HSP27; HSPB1）的特征是分子伴侣，当它们承受各种压力（例如化学疗法）时，它们会修饰细胞中其他蛋白质的结构和功能。虽然抗肿瘤药吉西他滨的给药已成为晚期胰腺癌患者的标准治疗方法，但越来越多的证据表明HSP27在对吉西他滨的化学敏感性中起关键作用。此外，吉西他滨诱导的磷酸化HSP27与胰腺癌细胞生长的抑制有关。在这篇综述中，我们总结了磷酸化的HSP27以及HSP27在胰腺癌化学敏感性调节中的作用。

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