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首页> 外文期刊>International Journal of Molecular Sciences >The Role of bFGF in the Excessive Activation of Astrocytes Is Related to the Inhibition of TLR4/NFκB Signals
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The Role of bFGF in the Excessive Activation of Astrocytes Is Related to the Inhibition of TLR4/NFκB Signals

机译：bFGF在星形胶质细胞过度活化中的作用与抑制TLR4 /NFκB信号有关

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摘要

Astrocytes have critical roles in immune defense, homeostasis, metabolism, and synaptic remodeling and function in the central nervous system (CNS); however, excessive activation of astrocytes with increased intermediate filaments following neuronal trauma, infection, ischemia, stroke, and neurodegenerative diseases results in a pro-inflammatory environment and promotes neuronal death. As an important neurotrophic factor, the secretion of endogenous basic fibroblast growth factor (bFGF) contributes to the protective effect of neuronal cells, but the mechanism of bFGF in reactive astrogliosis is still unclear. In this study, we demonstrated that exogenous bFGF attenuated astrocyte activation by reducing the expression of glial fibrillary acidic protein (GFAP) and other markers, including neurocan and vimentin, but not nestin and decreased the levels of pro-inflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), via the regulation of the upstream toll-like receptor 4uclear factor κB (TLR4/NFκB) signaling pathway. Our study suggests that the function of bFGF is not only related to the neuroprotective and neurotrophic effect but also involved in the inhibition of excessive astrogliosis and glial scarring after neuronal injury.
机译：星形胶质细胞在中枢神经系统（CNS）的免疫防御，体内平衡，代谢和突触重塑和功能中起关键作用。然而，在神经元外伤，感染，局部缺血，中风和神经退行性疾病之后，星形胶质细胞过度活化，中间丝增多，导致促炎环境并促进神经元死亡。作为重要的神经营养因子，内源性碱性成纤维细胞生长因子（bFGF）的分泌有助于神经元细胞的保护作用，但bFGF在反应性星形胶质增生中的机制仍不清楚。在这项研究中，我们证明了外源性bFGF通过降低神经胶质原纤维酸性蛋白（GFAP）和其他标志物（包括Neurocan和波形蛋白）的表达而减弱了星形胶质细胞的活化，但未抑制Nestin并降低了促炎性细胞因子（如白介素- 6（IL-6）和肿瘤坏死因子-α（TNF-α），通过调节上游toll样受体4 /核因子κB（TLR4 /NFκB）信号通路来实现。我们的研究表明，bFGF的功能不仅与神经保护和神经营养作用有关，而且还与神经元损伤后过度星形胶质沉着和神经胶质瘢痕形成的抑制有关。

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