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首页> 外文期刊>International Journal of Molecular Sciences >Hepatoma-Derived Growth Factor: Its Possible Involvement in the Progression of Hepatocellular Carcinoma
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Hepatoma-Derived Growth Factor: Its Possible Involvement in the Progression of Hepatocellular Carcinoma

机译：肝细胞源性生长因子：其可能参与肝细胞癌的进展

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The development of hepatocellular carcinoma (HCC) is an important complication of viral infection induced by hepatitis virus C, and our major research theme is to identify a new growth factor related to the progression of HCC. HDGF (hepatoma-derived growth factor) is a novel growth factor that belongs to a new gene family. HDGF was initially purified from the conditioned medium of a hepatoma cell line. HDGF promotes cellular proliferation as a DNA binding nuclear factor and a secreted protein acting via a receptor-mediated pathway. HDGF is a unique multi-functional protein that can function as a growth factor, angiogenic factor and anti-apoptotic factor and it participates in the development and progression of various malignant diseases. The expression level of HDGF may be an independent prognostic factor for predicting the disease-free and overall survival in patients with various malignancies, including HCC. Furthermore, the overexpression of HDGF promotes the proliferation of HCC cells, while a reduction in the HDGF expression inhibits the proliferation of HCC cells. This article provides an overview of the characteristics of HDGF and describes the potential role of HDGF as a growth-promoting factor for HCC.
机译：肝细胞癌（HCC）的发展是由丙型肝炎病毒引起的病毒感染的重要并发症，我们的主要研究主题是确定与HCC进程有关的新生长因子。 HDGF（肝癌衍生的生长因子）是一种新的生长因子，属于一个新的基因家族。 HDGF首先从肝癌细胞系的条件培养基中纯化。 HDGF促进细胞增殖，成为一种DNA结合核因子和一种通过受体介导的途径起作用的分泌蛋白。 HDGF是一种独特的多功能蛋白，可以充当生长因子，血管生成因子和抗凋亡因子，并且参与各种恶性疾病的发生和发展。 HDGF的表达水平可能是预测包括HCC在内的各种恶性肿瘤患者无病生存和总体生存的独立预后因素。此外，HDGF的过表达促进HCC细胞的增殖，而HDGF表达的降低抑制HCC细胞的增殖。本文概述了HDGF的特性，并描述了HDGF作为肝癌生长促进因子的潜在作用。

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