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首页> 外文期刊>International Journal of Molecular Sciences >25-Hydroxyvitamin D3 Levels, BsmI Polymorphism and Insulin Resistance in Brazilian Amazonian Children
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25-Hydroxyvitamin D3 Levels, BsmI Polymorphism and Insulin Resistance in Brazilian Amazonian Children

机译：巴西亚马逊地区儿童25-羟维生素D 3 水平，BsmI多态性和胰岛素抵抗

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Vitamin D is associated with a wide range of other functions beyond bone development. We evaluated the factors associated with 25-hydroxyvitamin D levels in 974 children aged ≤10 years and the impact of BsmI polymorphism of the vitamin D receptor (VDR) gene (rs1544410) on metabolic parameters in a subsample (n: 430) with a follow-up 2 years later from the initial population-based cross-sectional study. Multiple linear regression models were used in the analyses. The prevalence (95% CI) of vitamin D deficiency, insufficiency and sufficiency of children was 11.1% (9.2–13.2), 21.8% (19.2–24.5) and 67.2% (64.1–70.1), respectively. Overall, 23% of the variation in serum 25-hydroxyvitamin D concentrations was accounted for by BsmI polymorphism β = −0.053 (95% CI) (−0.100, −0.006), maternal schooling (≥9 years) β = 0.100 (0.039, 0.161), serum vitamin E β = 0.478 (0.381, 0.574), total cholesterol concentration β = 0.232 (0.072, 0.393) and serum folate β = 0.064 (0.013, 0.115). BsmI polymorphism was positively associated with HOMA-IR β = 0.122 (0.002, 0.243) and fasting glucose concentration β = 1.696 (0.259, 3.133). In conclusion, variables related to socioeconomic level, the presence of the allele risk for BsmI and other nutrient concentrations were associated with serum 25-hydroxyvitamin D concentrations. Our results suggest that BsmI polymorphism is correlated with metabolic outcomes.
机译：维生素D除了骨骼发育以外，还具有其他多种功能。我们评估了974名≤10岁儿童中25-羟基维生素D水平的相关因素以及维生素D受体（VDR）基因（rs1544410）的BsmI多态性对子样本（n：430）代谢参数的影响，以下内容从最初的基于人群的横断面研究开始的两年后分析中使用了多个线性回归模型。儿童维生素D缺乏，不足和充足的患病率（95％CI）分别为11.1％（9.2-13.2），21.8％（19.2-24.5）和67.2％（64.1-70.1）。总体而言，血清25-羟基维生素D浓度变化的23％是BsmI多态性β= -0.053（95％CI）（-0.100，-0.006），孕产学历（≥9岁）β= 0.100（0.039， 0.161），血清维生素Eβ= 0.478（0.381，0.574），总胆固醇浓度β= 0.232（0.072，0.393）和血清叶酸β= 0.064（0.013，0.115）。 BsmI多态性与HOMA-IRβ= 0.122（0.002，0.243）和空腹血糖浓度β= 1.696（0.259，3.133）正相关。总之，与社会经济水平，BsmI等位基因风险的存在和其他营养物浓度相关的变量与血清25-羟基维生素D浓度相关。我们的结果表明，BsmI基因多态性与代谢结果相关。

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