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首页> 外文期刊>International Journal of Molecular Sciences >Obesity and Its Potential Effects on Antidepressant Treatment Outcomes in Patients with Depressive Disorders: A Literature Review
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Obesity and Its Potential Effects on Antidepressant Treatment Outcomes in Patients with Depressive Disorders: A Literature Review

机译：肥胖及其对抑郁症患者抗抑郁治疗结果的潜在影响：文献综述

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摘要

Accumulating evidence regarding clinical, neurobiological, genetic, and environmental factors suggests a bidirectional link between obesity and depressive disorders. Although a few studies have investigated the link between obesity/excess body weight and the response to antidepressants in depressive disorders, the effect of weight on treatment response remains poorly understood. In this review, we summarized recent data regarding the relationship between the response to antidepressants and obesity/excess body weight in clinical studies of patients with depressive disorders. Although several studies indicated an association between obesity/excess body weight and poor antidepressant responses, it is difficult to draw definitive conclusions due to the variability of subject composition and methodological differences among studies. Especially, differences in sex, age and menopausal status, depressive symptom subtypes, and antidepressants administered may have caused inconsistencies in the results among studies. The relationship between obesity/excess body weight and antidepressant responses should be investigated further in high-powered studies addressing the differential effects on subject characteristics and treatment. Moreover, future research should focus on the roles of mediating factors, such as inflammatory markers and neurocognitive performance, which may alter the antidepressant treatment outcome in patients with comorbid obesity and depressive disorder.
机译：关于临床，神经生物学，遗传和环境因素的越来越多的证据表明，肥胖与抑郁症之间存在双向联系。尽管一些研究调查了肥胖/超重与抑郁症中抗抑郁药反应之间的联系，但体重对治疗反应的影响仍然知之甚少。在这篇综述中，我们总结了有关抑郁症患者临床研究中抗抑郁药反应与肥胖/体重过重之间关系的最新数据。尽管有几项研究表明肥胖/超重与抗抑郁反应不良之间存在关联，但由于研究对象之间的差异和研究方法的差异，很难得出明确的结论。尤其是，性别，年龄和绝经状态，抑郁症状亚型和抗抑郁药的使用差异可能导致研究结果不一致。肥胖/过量体重与抗抑郁药反应之间的关系应在有关对受试者特征和治疗的不同影响的高能研究中进一步研究。此外，未来的研究应集中在诸如炎症标志物和神经认知功能等中介因素的作用上，这些因素可能会改变合并症肥胖症和抑郁症患者的抗抑郁治疗结果。

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