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首页> 外文期刊>International Journal of Molecular Sciences >Connecting the Dots: From DNA Damage and Repair to Aging
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Connecting the Dots: From DNA Damage and Repair to Aging

机译：连接点：从DNA损伤和修复到老化

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摘要

Mammalian cells evolve a delicate system, the DNA damage response (DDR) pathway, to monitor genomic integrity and to prevent the damage from both endogenous end exogenous insults. Emerging evidence suggests that aberrant DDR and deficient DNA repair are strongly associated with cancer and aging. Our understanding of the core program of DDR has made tremendous progress in the past two decades. However, the long list of the molecules involved in the DDR and DNA repair continues to grow and the roles of the new “dots” are under intensive investigation. Here, we review the connection between DDR and DNA repair and aging and discuss the potential mechanisms by which deficient DNA repair triggers systemic effects to promote physiological or pathological aging.
机译：哺乳动物细胞进化出一个脆弱的系统，即DNA损伤反应（DDR）通路，以监测基因组完整性并防止内源性末端外源性损伤造成的损害。新兴证据表明，异常的DDR和不足的DNA修复与癌症和衰老密切相关。在过去的二十年中，我们对DDR核心计划的了解取得了巨大进展。但是，参与DDR和DNA修复的分子的清单越来越长，新的“点”的作用正在深入研究中。在这里，我们审查了DDR与DNA修复和衰老之间的联系，并讨论了缺陷DNA修复触发全身效应以促进生理或病理学衰老的潜在机制。

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