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首页> 外文期刊>Investigative ophthalmology & visual science >In Vivo Photovoltaic Performance of a Silicon Nanowire Photodiode–Based Retinal Prosthesis
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In Vivo Photovoltaic Performance of a Silicon Nanowire Photodiode–Based Retinal Prosthesis

机译：基于硅纳米线光电二极管的视网膜假体的体内光伏性能

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Purpose : For more than 20 years, there has been an international, multidisciplinary effort to develop retinal prostheses to restore functional vision to patients blinded by retinal degeneration. We developed a novel subretinal prosthesis with 1512 optically addressed silicon nanowire photodiodes, which transduce incident light into an electrical stimulation of the remaining retinal circuitry. This study was conducted to evaluate the efficacy of optically driving the subretinal prosthesis to produce visual cortex activation via electrical stimulation of the retina. Methods : We measured electrically evoked potential responses (EEPs) in rabbit visual cortex in response to illumination of the subretinal nanowire prosthesis with pulsed 852-nm infrared (IR) light. We compared the EEP responses to visually evoked potential responses (VEPs) to pulsed 532-nm visible light (positive control) and pulsed 852-nm IR light (negative control). Results : Activating the devices with IR light produced EEP responses with a significantly higher trough-to-peak amplitude (54.17 ± 33.4 μV) than IR light alone (24.07 ± 22.1 μV) or background cortical activity (23.22 ± 17.2 μV). EEP latencies were significantly faster than focal VEP latencies. Focal VEPs produced significantly higher amplitudes (94.88 ± 43.3 μV) than EEPs. We also demonstrated how an electrode placed on the cornea can be used as a noninvasive method to monitor the function of the implant. Conclusions : These results show that subretinal electrical stimulation with nanowire electrodes can elicit EEPs in the visual cortex, providing evidence for the viability of a subretinal nanowire prosthetic approach for vision restoration.
机译：目的：20多年来，国际上开展了多学科的努力来开发视网膜假体，以恢复因视网膜变性致盲的患者的功能视力。我们开发了一种新颖的视网膜下假体，其中包含1512个光学寻址的硅纳米线光电二极管，可将入射光转换成对剩余视网膜电路的电刺激。进行这项研究以评估光学驱动视网膜下假体通过视网膜的电刺激产生视觉皮层激活的功效。方法：我们测量了兔视觉皮层中的电诱发电位响应（EEP），以响应脉冲852-nm红外（IR）光照射视网膜下纳米线假体。我们将EEP响应与视觉诱发电位响应（VEP）进行了比较，分别针对脉冲532 nm可见光（阳性对照）和脉冲852 nm红外光（阴性对照）。结果：用红外光激活设备会产生EEP响应，其波峰间幅度（54.17±33.4μV）明显高于单独使用红外光（24.07±22.1μV）或背景皮层活动（23.22±17.2μV）。 EEP延迟比VEP延迟显着快。聚焦VEP产生的振幅（94.88±43.3μV）比EEP高得多。我们还演示了如何将放置在角膜上的电极用作监视植入物功能的非侵入性方法。结论：这些结果表明，用纳米线电极对视网膜下进行电刺激可在视觉皮层中诱发EEP，从而为视网膜下纳米线假体修复视力的可行性提供了证据。

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