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Venezuelan Equine Encephalitis Virus Infection of Cotton Rats

机译：委内瑞拉马脑炎病毒感染棉鼠

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Venezuelan equine encephalitis virus (VEEV) is an emerging pathogen of equids and humans, but infection of its rodent reservoir hosts has received little study. To de-termine whether responses to infection vary among geo-graphic populations, we inoculated 3 populations of cotton rats with 2 enzootic VEEV strains (Co97-0054 [enzootic ID subtype] and 68U201 [enzootic IE subtype]). The 3 popula-tions were offspring from wild-caught cotton rats collected in a VEE-enzootic area of south Florida, USA; wild-caught cotton rats from a non–VEE-enzootic area of Texas, USA; and commercially available (Harlan) colony-reared cotton rats from a non–VEE-enzootic region. Although each popu-lation had similar early viremia titers, no detectable disease developed in the VEE-sympatric Florida animals, but severe disease and death affected the Texas and Harlan animals. Our fi ndings suggest that the geographic origins of cotton rats are important determinants of the outcome of VEE in-fection and reservoir potential of these rodents
机译：委内瑞拉马脑炎病毒（VEEV）是马和人的新兴病原体，但其啮齿动物宿主的感染尚未得到研究。为了确定不同人群之间对感染的反应是否有所不同，我们给了3个棉鼠种群接种了2种VEEV菌株（Co97-0054 [enzootic ID亚型]和68U201 [enzootic IE亚型]）。这3个种群是在美国南佛罗里达州的VEE疫区采集的野外捕获的棉鼠的后代。来自美国得克萨斯州非VEE疫区的野生野生棉鼠;以及来自非VEE动物园地区的市售（Harlan）集落饲养的棉鼠。尽管每种人群的早期病毒血症滴度相似，但在VEE繁殖的佛罗里达州动物中未发现可检测到的疾病，但严重的疾病和死亡影响了德克萨斯州和哈兰动物。我们的发现表明，棉鼠的地理起源是这些啮齿动物的VEE感染结果和储藏潜力的重要决定因素。

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