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Tropheryma whipplei Genotypes 1 and 3, Central Europe

机译:中风鞭原体基因型1和3

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To the Editor: Tropheryma whipplei causes Whipple disease, a rare multisystemic disorder that affects mainly middle-aged white men and is most widely distributedin Europe and North America (1). In the general population of France, T. whipplei DNA was found in 2%–4% of stool samples and T. whipplei– specific antibodies were found in 51% of serum samples (2). Still, the prevalence of classic Whipple disease, which causes arthralgia, diarrhea, and weight loss, remains extremely low (1). Whipple disease has 4 known manifestations: 1) classic Whipple disease; 2) focused chronic infections, mainly endocarditis; 3) acute infections, such as gastroenteritis, bacteremia, and pneumonia; and 4) asymptomatic T. whipplei carriage in healthy persons (1–5). T. whipplei is thought to be transmitted through oral and oro–fecal routes by human-tohuman contact (2,6).
机译:致编者:惠氏周围神经病引起了Whipple病,这是一种罕见的多系统疾病,主要影响中年白人,在欧洲和北美分布最广泛(1)。在法国的普通人群中,在2%–4%的粪便样本中发现了T. whipplei DNA,在51%的血清样本中发现了T. whipplei特异性抗体(2)。尽管如此,引起关节痛,腹泻和体重减轻的经典Whipple疾病的患病率仍然极低(1)。 Whipple病有4种已知表现:1)经典的Whipple病; 2)重点慢性感染,主要是心内膜炎; 3)急性感染,例如肠胃炎,菌血症和肺炎; 4)健康人无症状的鞭毛鞭毛虫携带(1-5)。人们认为鞭状鞭毛虫是通过人与人之间的接触通过口头和粪便途径传播的(2,6)。

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