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首页> 外文期刊>Emerging Infectious Diseases >Novel Retinal Lesion in Ebola Survivors, Sierra Leone, 2016
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Novel Retinal Lesion in Ebola Survivors, Sierra Leone, 2016

机译：埃博拉幸存者中的新型视网膜病变，塞拉利昂，2016年

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摘要

We conducted a case–control study in Freetown, Sierra Leone, to investigate ocular signs in Ebola virus disease (EVD) survivors. A total of 82 EVD survivors with ocular symptoms and 105 controls from asymptomatic civilian and military personnel and symptomatic eye clinic attendees underwent ophthalmic examination, including widefield retinal imaging. Snellen visual acuity was < 6/7.5 in 75.6% (97.5% CI 63%–85.7%) of EVD survivors and 75.5% (97.5% CI 59.1%–87.9%) of controls. Unilateral white cataracts were present in 7.4% (97.5% CI 2.4%–16.7%) of EVD survivors and no controls. Aqueous humor from 2 EVD survivors with cataract but no anterior chamber inflammation were PCR-negative for Zaire Ebola virus, permitting cataract surgery. A novel retinal lesion following the anatomic distribution of the optic nerve axons occurred in 14.6% (97.5% CI 7.1%–25.6%) of EVD survivors and no controls, suggesting neuronal transmission as a route of ocular entry.
机译：我们在塞拉利昂弗里敦进行了一项病例对照研究，以调查埃博拉病毒病（EVD）幸存者的眼部症状。共有82名有眼部症状的EVD幸存者和无症状的文职和军事人员以及有症状的眼科诊所参加者的105名对照接受了眼科检查，包括宽视野视网膜成像。在EVD幸存者中，有75.6％（97.5％CI 63％–85.7％）和对照组的75.5％（97.5％CI 59.1％–87.9％）的Snellen视敏度<6 / 7.5。 EVD幸存者中有7.4％（97.5％CI 2.4％–16.7％）存在单侧白内障，无对照组。 2名患有白内障但未发生前房炎症的EVD幸存者的房水对扎伊尔埃博拉病毒呈PCR阴性，可进行白内障手术。视神经轴突解剖分布后发生的新型视网膜病变发生在14.6％（97.5％CI 7.1％–25.6％）的EVD幸存者中，并且没有对照组，提示神经元传播是眼部进入的途径。

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