...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Emerging Infectious Diseases >Prediction of Protection against Asian Enterovirus 71 Outbreak Strains by Cross-neutralizing Capacity of Serum from Dutch Donors, The Netherlands
【24h】

Prediction of Protection against Asian Enterovirus 71 Outbreak Strains by Cross-neutralizing Capacity of Serum from Dutch Donors, The Netherlands

机译：通过交叉中和荷兰捐赠人血清的能力来预防亚洲肠道病毒71爆发株的预测

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Outbreaks of human enterovirus 71 (EV-71) in Asia are related to high illness and death rates among children. To gain insight into the potential threat for the population of Europe, we determined the neutralizing activity in intravenous immunoglobulin (IVIg) batches and individual serum samples from donors in the Netherlands against EV-71 strains isolated in Europe and in Asia. All IVIg batches and 41%, 79%, and 65% of serum samples from children ≤5 years of age, women of childbearing age, and HIV-positive men, respectively, showed high neutralizing activity against a Dutch C1 strain, confirming widespread circulation of EV-71 in the Netherlands. Asian B3–4 and C4 strains were efficiently cross-neutralized, predicting possible protection against extensive circulation and associated outbreaks of those types in Europe. However, C2 and C5 strains that had few mutations in the capsid region consistently escaped neutralization, emphasizing the importance of monitoring antigenic diversity among circulating EV-71 strains.
机译：在亚洲，人类肠道病毒71（EV-71）的爆发与儿童的高疾病和高死亡率有关。为了深入了解对欧洲人口的潜在威胁，我们确定了静脉免疫球蛋白（IVIg）批次和荷兰捐赠者对欧洲和亚洲分离出的EV-71菌株的单独血清样本的中和活性。所有IVIg批次以及分别来自5岁以下儿童，育龄妇女和HIV阳性男性的41％，79％和65％的血清样品均显示出对荷兰C1毒株的高中和活性，证实了广泛的循环在荷兰生产EV-71。亚洲的B3–4和C4菌株有效地交叉中和，预示可能针对欧洲的这类病毒的广泛传播和相关爆发提供保护。但是，衣壳区几乎没有突变的C2和C5株始终逃避中和，强调了监测循环EV-71株之间抗原多样性的重要性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号