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首页> 外文期刊>Emerging Infectious Diseases >Serologic Response to Culture Filtrate Antigens of Mycobacterium ulcerans during Buruli Ulcer Disease
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Serologic Response to Culture Filtrate Antigens of Mycobacterium ulcerans during Buruli Ulcer Disease

机译：布鲁氏溃疡病对溃疡分枝杆菌培养滤液抗原的血清学反应

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摘要

Buruli ulcer (BU) is an emerging necrotic skin disease caused by Mycobacterium ulcerans. To assess the potential for a serodiagnostic test, we measured the humoral immune response of BU patients to M. ulcerans antigens and compared this response with delayed-type hypersensitivity responses to both Burulin and PPD. The delayed-type hypersensitivity response generally supported the diagnosis of BU, with overall reactivity to Burulin in 28 (71.8%) of 39 patients tested, compared with 3 (14%) of 21 healthy controls. However, this positive skin test response was observed primarily in patients with healed or active disease, and rarely in patients with early disease (p=0.009). When tested for a serologic response to M. ulcerans culture filtrate, 43 (70.5%) of 61 BU patients had antibodies to these antigens, compared with 10 (37.0%) of 27 controls and 4 (30.8%) of 13 tuberculosis patients. There was no correlation between disease stage and the onset of this serum antibody response. Our findings suggest that serologic testing may be useful in the diagnosis and surveillance of BU.
机译：布鲁氏溃疡（BU）是一种由溃疡分枝杆菌引起的坏死性皮肤病。为了评估进行血清诊断的潜力，我们测量了BU患者对溃疡分枝杆菌抗原的体液免疫反应，并将该反应与对Burulin和PPD的迟发型超敏反应进行了比较。迟发型超敏反应通常支持BU的诊断，测试的39名患者中有28名（71.8％）对Burulin有总体反应性，而21名健康对照者中只有3名（14％）。但是，这种阳性的皮肤测试反应主要在已治愈或活动性疾病的患者中观察到，而在早期疾病的患者中很少见（p = 0.009）。当测试对溃疡分枝杆菌培养物滤液的血清学反应时，61名BU患者中有43名（70.5％）对这些抗原具有抗体，而27名对照中有10名（37.0％）和13名结核病患者中有4名（30.8％）。在疾病阶段与该血清抗体反应的发作之间没有相关性。我们的发现表明，血清学检查可能对BU的诊断和监测有用。

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