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Specimen Collection for Electron Microscopy

机译:电子显微镜标本采集

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To the Editor: As virologists whose specialties include diagnostic electron microscopy (EM), we read with interest the discussion on bioterrorism scenarios (1,2) and the subsequent note by Marshall and Catton (3) on the rapid EM diagnostic process used for smallpox (1). EM diagnostics for viral agents offer an open, undirected view; a catch-all method; and speed. A negative stain preparation may be made and a result could be obtained within 5 minutes of the specimen’s arrival in the EM laboratory. As suggested by Marshall and Catton, however, success depends as much on the quality of the sample collected as on the method of preparation and skill of the microscopist.
机译:致编辑:作为专门研究诊断电子显微镜(EM)的病毒学家,我们感兴趣地阅读了有关生物恐怖主义场景的讨论(1,2)以及随后的Marshall和Catton(3)关于用于天花的快速EM诊断过程的说明。 (1)。用于病毒制剂的EM诊断提供了开放,无方向的视图;全面的方法;和速度。可以准备负染色剂,并在样品到达EM实验室后的5分钟内获得结果。然而,正如Marshall和Catton所建议的那样,成功与否取决于所采集样品的质量以及显微镜技术人员的制备方法和技能。

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