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首页> 外文期刊>Emerging Infectious Diseases >High Prevalence of Penicillin-Nonsusceptible Streptococcus pneumoniae at a Community Hospital in Oklahoma
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High Prevalence of Penicillin-Nonsusceptible Streptococcus pneumoniae at a Community Hospital in Oklahoma

机译：俄克拉荷马州一家社区医院的青霉素-不敏感肺炎链球菌患病率高

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During 1997, Oklahoma City’s Hospital A reported penicillin-nonsusceptible Streptococcus pneumoniae in almost 67% of isolates. To confirm this finding, all Hospital A S. pneumoniae isolates from October 23, 1997, through February 19, 1998, were tested for antibiotic susceptibility and repeat-tested at two other hospital laboratories. Medical records of Hospital A patients with invasive S. pneumoniae infections during 1994 through 1997 were also reviewed. These data were compared with 1998 statewide sentinel hospital surveillance data for invasive S. pneumoniae. Of 48 S. pneumoniae isolates from Hospital A during October 23, 1997, through February 19, 1998, 31 (65%) were penicillin-nonsusceptible S. pneumoniae, and 23 (48%) were highly penicillin resistant. Similar prevalences were confirmed at the other hospital laboratories; however, significant interlaboratory differences were noted in the determination of third-generation cephalosporin susceptibility. During 1994 through 1997, a trend toward increasing penicillin nonsusceptibility (p <0.05) was noted among S. pneumoniae isolates from nursing home patients. During 1998, 85 (30%) of 282 invasive isolates reported to the state surveillance system were penicillinnonsusceptible S. pneumoniae; 33 (12%) were highly resistant. The increase in resistance observed is notable; the interlaboratory discrepancies are unexplained. To respond, a vaccination program was implemented at Hospital A, and vaccination efforts were initiated at nursing homes.
机译：在1997年期间，俄克拉荷马城医院A报告了几乎67％的分离株中没有青霉素敏感的肺炎链球菌。为了证实这一发现，对1997年10月23日至1998年2月19日的所有肺炎链球菌医院分离株进行了抗生素敏感性测试，并在另外两个医院实验室进行了重复测试。还回顾了1994年至1997年期间A医院侵袭性肺炎链球菌感染的病历。将这些数据与1998年全州前哨医院侵袭性肺炎链球菌的监测数据进行了比较。 1997年10月23日至1998年2月19日，从医院A分离出的48株肺炎链球菌中，有31例（65％）对青霉素不敏感的肺炎链球菌，对23株（48％）的青霉素耐药。其他医院实验室也证实了类似的患病率。然而，在确定第三代头孢菌素敏感性时，实验室间存在显着差异。在1994年到1997年期间，在从疗养院患者中分离出的肺炎链球菌中，青霉素的非药敏性呈增加趋势（p <0.05）。在1998年期间，报告给国家监视系统的282株侵入性分离株中有85株（30％）是对青霉素不敏感的肺炎链球菌。 33（12％）具有高度抵抗力。观察到的电阻增加明显;实验室间的差异尚无法解释。作为回应，甲医院实施了疫苗接种计划，并在疗养院开始了疫苗接种工作。

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