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首页> 外文期刊>Emerging Infectious Diseases >Atypical Enteropathogenic Escherichia coli: Typical Pathogens?
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Atypical Enteropathogenic Escherichia coli: Typical Pathogens?

机译：非典型肠致病性大肠杆菌：典型病原体？

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摘要

Escherichia coli is both the most abundant facultativecommensal of the human gastrointestinal tract and themost common bacterial cause of human diarrhea (1).However, precise recognition of E. coli pathotypesremains problematic. Enteropathogenic E. coli (EPEC),classically associated with outbreaks of infant diarrhea,harbors distinctive chromosomal (the locus of enterocyteeffacement, or LEE island) and plasmidborne (residing onthe EPEC adherence factor, or EAF, plasmid) virulencefactors, which are linked by common gene regulators (1).At the Second International Conference on EPEC, held inS.o Paulo, Brazil, in 1995, the foremost authorities in thefield proclaimed the global importance of such "typical"EPEC (tEPEC) but pondered the clinical relevance ofstrains carrying only the LEE island (dubbed at that con-ference "atypical EPEC," or aEPEC) (2). Had aEPEC lostthe EAF plasmid. Had it incidentally acquired only frag-ments or incomplete packages of virulence-associatedgenes. Or were some aEPEC true pathogens of humans oranimals.
机译：大肠杆菌既是人类胃肠道最丰富的兼职手段，也是人类腹泻的最常见细菌病因（1），但是准确识别大肠杆菌病原体仍然存在问题。肠致病性大肠杆菌（EPEC），通常与婴儿腹泻的暴发有关，具有独特的染色体（肠上皮细胞形成的位点或LEE岛）和质粒传播的（位于EPEC粘附因子或EAF质粒上）毒力因子，这些因子通过常见基因调节剂（1）。在1995年于巴西圣保罗举行的第二届EPEC国际会议上，该领域的最高当局宣布了这种“典型” EPEC（tEPEC）的全球重要性，但考虑了携带菌株的临床意义只有LEE岛（在该会议上称为“非典型EPEC”或aEPEC）（2）。如果aEPEC丢失了EAF质粒。如果它只是偶然获得了碎片或与毒力相关基因的包装不完整。或者是人类动物的某些aEPEC真正病原体。

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