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Identifying the Sources of Tuberculosis in Young Children: A Multistate Investigation

机译：识别幼儿结核病的来源：多州调查

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To better understand the molecular epidemiology of tuberculosis (TB) transmission for culture-confirmedpatients <5 years of age, data were analyzed from a population-based study conducted in seven U.S. sitesfrom 1996 to 2000. Mycobacterium tuberculosis isolates were genotyped with IS6110-based restrictionfragment length polymorphism analysis and spoligotyping. Case-patient data were obtained from the Cen-ters for Disease Control and Prevention's national tuberculosis registry and health department records.Routine public health investigations conducted by local health departments identified suspected sourcepatients for 57 (51%) of 111 culture-confirmed patients <5 years of age. For 8 (15%) of 52 culture-con-firmed patients <5 years of age and their suspected source patients with complete genotyping results, gen-otypes suggested infection with different TB strains. Potential differences between sources for patients <5years of age and source patients that transmitted TB to adolescent and adult patients were identified
机译：为了更好地了解5岁以下的文化确诊患者的结核病（TB）传播分子流行病学，对1996年至2000年在美国七个地点进行的基于人群的研究数据进行了分析。对结核分枝杆菌分离株进行了基于IS6110的限制性片段基因分型长度多态性分析和基因分型。病例-患者数据来自疾病预防控制中心的国家结核病登记处和卫生部门的记录。地方卫生部门进行的常规公共卫生调查发现，在111名经文化确认的患者中，有57名（51％）被怀疑是源患者，<5岁。在52名经文化确认的年龄小于5岁的患者中，有8名（15％）及其可疑来源患者具有完整的基因分型结果，基因型提示感染了不同的TB菌株。确定了<5岁患者的来源与将结核病传播给青少年和成人患者的来源之间的潜在差异

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