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首页> 外文期刊>Emerging Infectious Diseases >Haemophilus influenzae Invasive Disease in the United States, 1994–1995: Near Disappearance of a Vaccine-Preventable Childhood Disease
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Haemophilus influenzae Invasive Disease in the United States, 1994–1995: Near Disappearance of a Vaccine-Preventable Childhood Disease

机译：1994-1995年美国流感嗜血杆菌侵袭性疾病：可预防疫苗的儿童疾病几乎消失

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We analyzed national Haemophilus influenzae (Hi) surveillance data from 1994 and 1995 to describe the epidemiology of Hi invasive disease among persons of all ages. Serotype data were available for 376 (56%) of 669 reported Hi cases among children aged 4 years or younger; 184 (49%) were H. influenzae type b (Hib). Among children aged 4 or younger, incidence (per 100,000) of all Hi invasive disease was 1.8 in 1994 and 1.6 (p < 0.05) in 1995. Children aged 5 months or younger had the highest average annual incidence rate of Hib invasive disease (2.2 per 100,000); children aged 6 to 11 months had the next highest rate (1.2 per 100,000) (p < 0.05). Of 181 children with Hib invasive disease whose age in months was known, 85 (47%) were too young (aged 5 months or younger) to have completed a primary series with an Hib-containing vaccine. Of the 83 children with known vaccination status who were eligible to receive a primary series (aged 6 months or older), 52 (63%) were undervaccinated, and the remaining 31 (37%) had completed a primary series in which vaccine failed. Among persons aged 5 years or older with Hi invasive disease, the lowest average annual incidence was among those 20 to 39 years of age (0.15 per 100,000), and the highest was among those aged 80 years or older (2.26 per 100,000). Among persons aged 5 years or older, serotype data were available for 1,372 (71%) of the 1,940 Hi invasive disease cases; 159 (28%) of the 568 Hi cases with known serotype were due to Hib.
机译：我们分析了1994年和1995年的国家流感嗜血杆菌（Hi）监测数据，以描述各个年龄段的人的Hi侵袭性疾病的流行病学。 4岁或以下儿童中669例Hi病例中有376例（56％）有血清型数据。 184例（49％）为b型流感嗜血杆菌（Hib）。在4岁以下的儿童中，所有Hi侵袭性疾病的发生率（每100,000）在1994年为1.8，在1995年为1.6（p <0.05）。5个月以下的儿童Hib侵袭性疾病的年平均发病率最高（2.2）每100,000） 6至11个月大的儿童患病率次高（每10万人中有1.2例）（p <0.05）。在181个月大的Hib侵袭性疾病儿童中，有85名（47％）年龄太小（5个月或更小），无法完成含Hib疫苗的初次接种。在有资格接种初级疫苗的83名儿童中（6个月或更大），有52名儿童（63％）未接种疫苗，其余31名（37％）已完成了一次初级疫苗接种失败的疫苗。在患有Hi浸润性疾病的5岁或以上的人群中，年平均发病率最低的是20-39岁的人群（0.15 / 100,000），最高的是80岁或以上的人群（2.26 / 100,000）。在5岁或以上的人群中，有1940例Hi浸润性疾病病例中的1 372例（71％）的血清型数据可用。 568例血清型已知的Hi病例中有159例（28％）归因于Hib。

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