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Bordetella pertussis Isolates, Finland

机译:百日咳博德特氏菌分离株,芬兰

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To the Editor: Pertussis, orwhooping cough, is a highly conta-gious respiratory disease in humanscaused by Bordetella pertussis.Reemergence of pertussis has beenobserved in many countries with highvaccination coverage. In the UnitedStates, reported cases of pertussis inadolescents and adults have increasedsince the 1980s, despite increasinglyhigh rates of vaccination in infantsand children (1). At the same time,clinical B. pertussis isolates havebecome antigenically divergent fromvaccine strains (2,3). This observationhas raised the question of whethervaccination has caused selection forthe variant strains, and whether thereemergence of pertussis in vaccinat-ed populations is due to vaccinationnot protecting against these antigenicvariants as effectively as it protectsagainst vaccine type strains. On theother hand, vaccine-induced immuni-ty wanes over time, and pertussis isnot only a childhood disease but alsoa frequent cause of prolonged illnessin adults and adolescents today (4).
机译:致百日咳或百日咳是百日咳博德特氏菌引起的高度污染性呼吸道疾病。许多接种疫苗覆盖率很高的国家都观察到百日咳再次出现。在美国,尽管婴儿和儿童的疫苗接种率越来越高,但自1980年代以来,报告的青少年和成人百日咳病例有所增加(1)。同时,临床百日咳博德特氏菌分离株与疫苗株在抗原上也有所不同(2,3)。该观察提出了以下问题:疫苗是否引起了对变异株的选择,以及在疫苗接种人群中百日咳的出现是否是由于疫苗接种不能像保护疫苗类型的菌株那样有效地抵抗这些抗原变异。另一方面,随着时间的流逝,疫苗诱导的免疫力逐渐下降,百日咳不仅是儿童疾病,也是当今成人和青少年长期病的常见原因(4)。

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