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Diversification in Salmonella Typhimurium DT104

机译:鼠伤寒沙门氏菌DT104的多样化

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To the Editor: Multidrug-resistant(MDR) Salmonella Typhimuriumdefinitive phage type (DT) 104 withchromosomally encoded resistance toampicillin, chloramphenicol, strepto-mycin/spectinomycin, sulfonamides,and tetracyclines (ACSSpSuT) wasfirst identified and characterized inthe United Kingdom in the early1990s (1). MDR DT104 has subse-quently caused numerous outbreaksthroughout the world (1). The organ-ism is characterized by a distinctiveXba I-generated pulsed-field profile(PFP), designated Xtm 1 (2), carriageof the 90-kb S. Typhimurium serovar-specific plasmid (SSP), and presenceof the 43-kb Salmonella genomicisland 1 (SGI 1), which is composedof integrons containing, respectively,the ASu (blaCARB-2 and sul1) and SSp(aadA2) genes, with intervening plas-mid-derived genes coding for chlo-ramphenicol/florfenicol (cmlA) andtetracycline resistance (tetG) (1,3,4).The same genetic characteristics havebeen observed in MDR strains of theclosely related DTs 12 and 104b (5)and in some strains of phage typeU302 (4). All isolates of MDR DT104ACSSpSuT contain the same genecassettes irrespective of source orcountry of origin. Although MDRDT104 has declined during the last 5years, the organism remains the mostcommon MDR Salmonella in theUnited Kingdom and many otherEuropean countries (6).
机译:致编者:1990年代初在英国首次发现并鉴定了多重耐药性鼠伤寒沙门氏菌定性噬菌体(DT)类型,其具有对氨苄青霉素,氯霉素,链霉素/大观霉素,磺酰胺和四环素(ACSSpSuT)的染色体编码(1) )。随后,MDR DT104在全球范围内引起了众多爆发(1)。这种生物体的特征是独特的Xba I产生的脉冲场图谱(PFP),命名为Xtm 1(2),携带90 kb鼠伤寒沙门氏菌血清特异性质粒(SSP),并且存在43 kb沙门氏菌基因组岛1(SGI 1),由分别含有ASu(blaCARB-2和sul1)和SSp(aadA2)基因的整数组成,中间的plas-mid衍生基因编码氯-雷米尼考/氟苯尼考(cmlA)和四环素(tetG)(1,3,4)。在密切相关的DTs 12和104b(5)的MDR菌株和一些U302型噬菌体的菌株中观察到了相同的遗传特性(4)。不论来源或原产国,MDR DT104ACSSpSuT的所有分离株均包含相同的基因盒。尽管近五年来MDRDT104有所下降,但该生物仍然是英国和许多其他欧洲国家中最常见的MDR沙门氏菌(6)。

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