NmcA Carbapenem-hydrolyzing Enzyme in Enterobacter cloacae in North America

S. Pottumarthy; Ellen Smith Moland; Stefan Juretschko; Susan R. Swanzy; Kenneth S. Thomson; Thomas R. Fritsche

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NmcA Carbapenem-hydrolyzing Enzyme in Enterobacter cloacae in North America

机译：北美阴沟肠杆菌中的NmcA碳青霉烯水解酶

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An imipenem-resistant Enterobacter cloacae isolate was recovered from the blood of a patient with a hematologic malignancy. Analytical isoelectric focusing, inhibitor studies, hydrolysis, induction assays, and molecular sequencing methods confirmed the presence of a NmcA carbapenem-hydrolyzing enzyme. This first report of NmcA detected in North America warrants further investigation into its distribution and clinical impact.

机译：从患有血液系统恶性肿瘤的患者的血液中回收了对亚胺培南耐药的阴沟肠杆菌。等电聚焦分析，抑制剂研究，水解，诱导分析和分子测序方法证实了NmcA碳青霉烯水解酶的存在。在北美发现的NmcA的第一份报告值得进一步调查其分布和临床影响。

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《Emerging Infectious Diseases》 |2003年第8期|共4页
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S. Pottumarthy; Ellen Smith Moland; Stefan Juretschko; Susan R. Swanzy; Kenneth S. Thomson; Thomas R. Fritsche;
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1. AmpD is required for regulation of expression of NmcA, a carbapenem-hydrolyzing beta-lactamase of Enterobacter cloacae. [J] . Naas T, Massuard S, Garnier F, Antimicrobial agents and chemotherapy. . 2001,第10期

机译：AmpD是调节NmcA（阴沟肠杆菌的碳青霉烯水解β-内酰胺酶）表达所需的。
2. Plasmid-mediated carbapenem-hydrolyzing enzyme KPC-2 and ArmA 16S rRNA methylase conferring high-level aminoglycoside resistance in carbapenem-resistant Enterobacter cloacae in China [J] . Qiong Wu, Qingzhong Liu, Lizhong Han, Diagnostic microbiology and infectious disease . 2010,第3期

机译：质粒介导的碳青霉烯水解酶KPC-2和ArmA 16S rRNA甲基化酶可在中国对碳青霉烯类耐药的阴沟肠杆菌中赋予高水平的氨基糖苷抗性
3. Genetic and Biochemical Characterization of FRI-1, a Carbapenem-Hydrolyzing Class A beta-Lactamase from Enterobacter cloacae [J] . Dortet Laurent, Poirel Laurent, Abbas Samia, Antimicrobial agents and chemotherapy. . 2015,第12期

机译：泄殖腔肠杆菌碳青霉烯水解A类β-内酰胺酶FRI-1的遗传和生化特性
4. GROWTH ANALYSIS OF METHANOBREVIBACTER SMITHII, KLEBSIELLA PNUEMONIAE AND ENTEROBACTER CLOACAE ON-GROUND AND IN MICRO-GRAVITY [C] . Raghavi C H, Sourav Umashankar, Priyanshi Chaturvedi, IAF/IAA Space Life Sciences Symposium;International Astronautical Congress . 2020

机译：甲烷纤维素，猕猴桃肺炎和肠杆菌在地上和微重的生长分析
5. X ray structural analysis of beta-lactamase of Enterobacter cloacae P99 and penicillin binding to a target enzyme DD-peptidase of Streptomyces R61. [D] . Zhao, Haiching. 1988

机译：阴沟肠杆菌P99的β-内酰胺酶和青霉素与链霉菌R61的靶酶DD-肽酶结合的X射线结构分析。
6. NmcA Carbapenem-hydrolyzing Enzyme in Enterobacter cloacae in North America [O] . Sudha Pottumarthy, Ellen Smith Moland, Stefan Juretschko, 2003

机译：北美阴沟肠杆菌中的NmcA碳青霉烯水解酶
7. NmcA Carbapenem-hydrolyzing Enzyme in Enterobacter cloacae in North America1 [O] . Pottumarthy, Sudha, Moland, Ellen Smith, Juretschko, Stefan, 2003

机译：北美阴沟肠杆菌中的NmcA碳青霉烯水解酶1

NmcA Carbapenem-hydrolyzing Enzyme in Enterobacter cloacae in North America

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