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首页> 外文期刊>Emerging Infectious Diseases >Virulence Characteristics of Klebsiella and Clinical Manifestations of K. pneumoniae Bloodstream Infections
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Virulence Characteristics of Klebsiella and Clinical Manifestations of K. pneumoniae Bloodstream Infections

机译：克雷伯菌的毒力特征和肺炎克雷伯菌血流感染的临床表现

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We studied 455 consecutive episodes of Klebsiella pneumoniae bacteremia occurring in 7 countries. Commu-nity-acquired pneumonia and an invasive syndrome of liver abscess, meningitis, or endophthalmitis occurred only in Taiwan and South Africa. Infections by K1 and K2 capsular serotype, the mucoid phenotype, and aerobactin production were important determinants of virulence. The mucoid phe-notype was seen in 94% of isolates in patients with com-munity-acquired pneumonia and in 100% of isolates that caused the invasive syndrome in Taiwan and South Africa, compared with only 2% of isolates elsewhere. Mortality of mice injected with mucoid strains (69%) was strikingly higher than that occurring in mice injected with nonmucoid strains (3%, p<0.001). Differences in clinical features of bacteremic infection with K. pneumoniae are due to the virulence fac-tors expressed by the organism
机译：我们研究了在7个国家/地区连续发生的455例肺炎克雷伯菌菌血症。仅在台湾和南非，发生社区获得性肺炎和肝脓肿，脑膜炎或眼内炎的侵袭性综合征。 K1和K2荚膜血清型，粘液表型和气杆菌素产生的感染是毒力的重要决定因素。在台湾和南非，在社区获得性肺炎患者中有94％的分离株和100％引起侵袭性综合症的分离株中发现了粘液表型，而在其他地区只有2％的分离株中发现。注射粘液样菌株的小鼠的死亡率（69％）显着高于注射非粘液样菌株的小鼠的死亡率（3％，p <0.001）。肺炎克雷伯菌细菌感染临床特征的差异是由于该生物体表达的毒力因子所致

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