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Emericella quadrilineata as Cause of Invasive Aspergillosis

机译：四叶草（Emericella quadrilineata）是侵袭性曲霉病的原因

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We noted a cluster of 4 cases of infection or coloniza-tion by Emericella spp., identifi ed by sequence-based anal-ysis as E. quadrilineata. Sequence-based analysis of an in-ternational collection of 33 Emericella isolates identifi ed 12 as E. nidulans, all 12 of which had previously been identi-fi ed by morphologic methods as E. nidulans. For 12 isolates classifi ed as E. quadrilineata, only 6 had been previously identifi ed accordingly. E. nidulans was less susceptible than E. quadrilineata to amphotericin B (median MICs 2.5 and 0.5 mg/L, respectively, p<0.05); E. quadrilineata was less susceptible than E. nidulans to caspofungin (median MICs, 1.83 and 0.32 mg/L, respectively, p<0.05). These data in-dicate that sequence-based identifi cation is more accurate than morphologic examination for identifying Emericella spp. and that correct species demarcation and in vitro sus-ceptibility testing may affect patient management
机译：我们注意到有4例由Emericella spp。感染或定植的病例，通过基于序列的分析鉴定为E. quadrilineata。基于国际序列的33种紫花病菌分离物国际鉴定，鉴定出12种为构巢大肠埃希氏菌，以前通过形态学方法将其全部鉴定为构巢大肠埃希氏菌。对于12个分类为E.quadrilineata的菌株，以前仅相应地鉴定了6个。构巢曲霉对两性霉素B的敏感度不及四线曲霉（MIC分别为2.5和0.5 mg / L，p <0.05）。象E. nidulans一样，E。quadrilineata对卡泊芬净的敏感性较弱（中位数MIC分别为1.83和0.32 mg / L，p <0.05）。这些数据表明，基于序列的鉴定比形态学鉴定Emericella spp更准确。正确的物种划分和体外药敏试验可能会影响患者管理

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