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Hepatitis E Virus Genotype 1, Cuba

机译：戊型肝炎病毒基因型1，古巴

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To the Editor: Hepatitis E virus (HEV) causes acute viral hepatitis, which in rare cases leads to fulminant hepatitis with high death rates, espe-cially among women in their third trimester of pregnancy (1). Sporadic infections and epidemics have been reported from all parts of the world, especially Asia, Africa, and Latin America. Although indigenous hepa-titis E has rarely been observed in industrialized countries, higher than expected anti-HEV prevalence has been detected in these areas (1). In the Caribbean region, many countries in-cluding Cuba, Haiti, Guatemala, and Honduras have reported hepatitis E (2,3), but the viruses have not been characterized.The transmission of HEV is pri-marily fecal–oral, through contami-nated drinking water; limited zoonotic transmission has also been reported. Despite only 1 serotype, 4 major gen-otypes of HEV have been reported (1). Genotype 1 is mainly responsible for sporadic infections and large out-breaks in Asia and Africa. Genotype 2 was fi rst found in Mexico and later on the African continent. Genotypes 3 and 4 have been reported from the United States, Europe, China, Japan, and Taiwan; this group also includes the related swine HEV (1).
机译：致编者：戊型肝炎病毒（HEV）引起急性病毒性肝炎，在极少数情况下会导致暴发性肝炎，死亡率高，特别是在妊娠中期的女性中（1）。世界各地，特别是亚洲，非洲和拉丁美洲，都报告了零星的感染和流行病。尽管在工业化国家很少见到本地戊型肝炎，但在这些地区发现的抗-HEV流行率高于预期（1）。在加勒比地区，包括古巴，海地，危地马拉和洪都拉斯在内的许多国家都报告了戊型肝炎（2,3），但尚未鉴定出该病毒的特征。戊型肝炎病毒主要通过粪便通过粪便经口传播。 -指定饮用水;也有人报道了有限的人畜共患病传播。尽管只有1种血清型，但已报告了4种主要的HEV基因型（1）。基因型1主要导致亚洲和非洲的零星感染和大规模爆发。基因型2首先在墨西哥发现，随后在非洲大陆发现。已经从美国，欧洲，中国，日本和台湾报道了基因型3和4。该组还包括相关的猪HEV（1）。

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