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Molecular Evidence of Oysters as Vehicle of Norovirus GII.P17-GII.17

机译：牡蛎作为诺如病毒GII.P17-GII.17载体的分子证据

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To the Editor: Norovirus is the world’s leading cause of nonbacterial acute gastroenteritis (1). Since their emergence, GII.P17-GII.17 noroviruses have replaced the GII.4 Sydney 2012 variant as the dominating norovirus genotype in parts of Asia (2), although they have been detected only sporadically, in a limited number, on other continents (3).The major reservoir(s) of GII.17 that contribute to transmission are unknown, but it has been suggested that oysters and other bivalve shellfish are common vehicles for transmission of the emerging GII.17 viruses (2). In this study, we demonstrate the link between oysters and human disease by presenting molecular evidence of norovirus GII.P17-GII.17 in Denmark causing acute gastroenteritis, characterized by the sudden onset of vomiting with or without diarrhea after consumption of oysters. We further document molecular evidence providing linkage between norovirus detected in fecal samples from patients and food samples from imported oysters.
机译：致编者：诺如病毒是世界上非细菌性急性胃肠炎的主要原因（1）。自从出现以来，GII.P17-GII.17诺如病毒已取代GII.4 Sydney 2012变体，成为亚洲部分地区的主要诺如病毒基因型（2），尽管在其他大洲仅偶发地在少数地区被检测到。 （3）。导致传播的GII.17的主要水库是未知的，但有人建议牡蛎和其他双壳贝类是传播新兴GII.17病毒的常见媒介（2）。在这项研究中，我们通过提供诺如病毒GII.P17-GII.17在丹麦引起急性胃肠炎的分子证据，证明了牡蛎与人类疾病之间的联系，其特征是食用牡蛎后突然呕吐，有或没有腹泻。我们进一步记录了分子证据，这些证据提供了在患者粪便样本中检测到的诺如病毒与进口牡蛎食物样本之间的联系。

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