Fatal Accelerated Cirrhosis after Imported HEV Genotype 4 Infection

Ryan B. Perumpail; Aijaz Ahmed; John P. Higgins; Samuel K. So; J. Lynn Cochran; Jan Drobeniuc; Tonya R. Mixson-Hayden; Chong-Gee Teo

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Fatal Accelerated Cirrhosis after Imported HEV Genotype 4 Infection

机译：进口HEV基因型4感染后致命加速性肝硬化。

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To the Editor: Hepatitis E is a viral hepatitide that is endemic in many developing countries. In its classic form, it results from ingesting fecally contaminated water that carries hepatitis E virus (HEV), and it frequently resolves without treatment. When hepatitis E is imported to the United States, it originates mainly from persons who have acquired HEV genotype 1 infection from South Asia (1). We report imported HEV genotype 4 infection (Technical Appendix Figure, panel A) in a patient during which cirrhosis and fatal hepatic decompensation ensued.

机译：致编辑：戊型肝炎是一种病毒性肝炎，在许多发展中国家都很流行。它的经典形式是食入带有E型肝炎病毒（HEV）的粪便污染的水，并且经常不经治疗即可分解。当戊型肝炎进口到美国时，它主要来源于从南亚获得了HEV基因型1感染的人（1）。我们报告了发生肝硬化和致命性肝失代偿的患者中导入的HEV基因型4感染（技术附录图，图A）。

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《Emerging Infectious Diseases》 |2015年第9期|共3页
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Ryan B. Perumpail; Aijaz Ahmed; John P. Higgins; Samuel K. So; J. Lynn Cochran; Jan Drobeniuc; Tonya R. Mixson-Hayden; Chong-Gee Teo;
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1. HEV superinfection accelerates disease progression in patients with chronic HBV infection and increases mortality in those with cirrhosis [J] . Journal of Hepatology: The Journal of the European Association for the Study of the Liver . 2020,第6期

机译：HEV SuperInfection加速慢性HBV感染患者的疾病进展，增加了肝硬化的死亡率
2. A nationwide survey of hepatitis E virus (HEV) infection in wild boars in Japan: identification of boar HEV strains of genotypes 3 and 4 and unrecognized genotypes. [J] . Jirintai, Nishizawa T, Okamoto H Archives of virology . 2011,第8期

机译：日本全国野猪戊型肝炎病毒（HEV）感染的全国性调查：鉴定3型和4型以及未知基因型的公猪HEV株。
3. A nationwide survey of hepatitis E virus (HEV) infection in wild boars in Japan: identification of boar HEV strains of genotypes 3 and 4 and unrecognized genotypes [J] . Yukihiro Sato, Hiroyuki Sato, Keisuke Naka, Archives of Virology . 2011,第8期

机译：日本野猪戊型肝炎病毒（HEV）感染的全国性调查：鉴定基因型3和4以及未知基因型的公猪HEV株
4. Responses of apricot genotypes to brown fruit rot (Monilinia spp.) to artificial and natural infections [C] . R. Vavra, H. Drahosova, A. Skrivanova, International Conference on Organic Fruit-Growing . 2012

机译：杏基因型对棕色水果腐的反应（Monilinia SPP。）对人工和自然感染
5. Hepatitis C infection in injection drug users from southern China: Low viral clearance, multiple genotypes and mixed genotype infections. [D] . Garten, Rebecca JoAnne. 2005

机译：中国南部注射吸毒者的丙型肝炎感染：病毒清除率低，多种基因型和混合基因型感染。
6. Fatal Accelerated Cirrhosis after Imported HEV Genotype 4 Infection [O] . Ryan B. Perumpail, Aijaz Ahmed, John P. Higgins, 2015

机译：进口HEV基因型4感染后致命加速性肝硬化。
7. Prior infection of pigs with a genotype 3 swine hepatitis E virus (HEV) protects against subsequent challenges with homologous and heterologous genotypes 3 and 4 human HEV [O] . Brenton J. Sanford, Barbara A. Dryman, Yao-Wei Huang, 2011

机译：用基因型3猪乙型肝炎病毒（HEV）之前感染猪（HEV），免受随后与同源和异源基因型3和4人HEV的挑战

Fatal Accelerated Cirrhosis after Imported HEV Genotype 4 Infection

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