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首页> 外文期刊>Emerging Infectious Diseases >Characterization of Flagella Produced by Clinical Strains of Stenotrophomonas maltophilia
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Characterization of Flagella Produced by Clinical Strains of Stenotrophomonas maltophilia

机译：嗜麦芽窄食单胞菌临床菌株产生的鞭毛的表征

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Stenotrophomonas maltophilia is an emerging nosocomial pathogen associated with opportunistic infec-tions in patients with cystic fibrosis, cancer, and HIV. Adherence of this organism to abiotic surfaces suchas medical implants and catheters represents a major risk for hospitalized patients. The adhesive surfacefactors involved in adherence of these bacteria are largely unknown, and their flagella have not yet beencharacterized biochemically and antigenically. We purified and characterized the flagella produced by S.maltophilia clinical strains. The flagella filaments are composed of a 38-kDa subunit, SMFliC, and analysisof its N-terminal amino acid sequence showed considerable sequence identity to the flagellins of Serratiamarcescens (78.6%), Escherichia coli, Proteus mirabilis, Shigella sonnei (71.4%), and Pseudomonasaeruginosa (57.2%). Ultrastructural analysis by scanning electron microscopy of bacteria adhering to plas-tic showed flagellalike structures within the bacterial clusters, suggesting that flagella are produced as thebacteria spread on the abiotic surface
机译：嗜麦芽窄食单胞菌是一种新兴的医院病原体，与囊性纤维化，癌症和HIV患者的机会性感染有关。这种生物粘附到非生物表面（例如医疗植入物和导管）上代表住院患者的主要风险。这些细菌的粘附所涉及的粘附表面因子在很大程度上是未知的，并且它们的鞭毛尚未经过生物化学和抗原学表征。我们纯化和表征了嗜麦芽孢杆菌临床菌株产生的鞭毛。鞭毛细丝由38kDa的亚基SMFliC组成，对其N端氨基酸序列的分析显示，其与沙雷氏菌（78.6％），大肠杆菌，变形杆菌，痢疾志贺菌（71.4％）的鞭毛蛋白具有相当的序列同一性，和铜绿假单胞菌（57.2％）。通过扫描电子显微镜对附着在塑料上的细菌进行超微结构分析，发现细菌簇内存在鞭毛状结构，这表明鞭毛是随着细菌在非生物表面扩散而产生的。

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