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首页> 外文期刊>Emerging Infectious Diseases >Susceptibility of North American Ducks and Gulls to H5N1 Highly Pathogenic Avian Influenza Viruses
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Susceptibility of North American Ducks and Gulls to H5N1 Highly Pathogenic Avian Influenza Viruses

机译：北美鸭和海鸥对H5N1高致病性禽流感病毒的敏感性

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摘要

Since 2002, H5N1 highly pathogenic avian influenza(HPAI) viruses have been associated with deaths in numer-ous wild avian species throughout Eurasia. We assessedthe clinical response and extent and duration of viral shed-ding in 5 species of North American ducks and laughinggulls (Larus atricilla) after intranasal challenge with 2 AsianH5N1 HPAI viruses. Birds were challenged at ≈10 to 16weeks of age, consistent with temporal peaks in virusprevalence and fall migration. All species were infected, butonly wood ducks (Aix sponsa) and laughing gulls exhibitedillness or died. Viral titers were higher in oropharyngealswabs than in cloacal swabs. Duration of viral shedding(1–10 days) increased with severity of clinical disease.Both the hemagglutination-inhibition (HI) and agar gel pre-cipitin (AGP) tests were able to detect postinoculation anti-bodies in surviving wood ducks and laughing gulls; the HItest was more sensitive than the AGP in the remaining 4species
机译：自2002年以来，H5N1高致病性禽流感（HPAI）病毒已与整个欧亚大陆的众多野生禽类死亡相关。我们评估了用2种AsianH5N1 HPAI病毒进行鼻内攻击后5种北美鸭和笑鸥（Larus atricilla）的临床反应以及病毒脱落的程度和持续时间。在大约10至16周龄时对鸟类进行了挑战，这与病毒流行和秋季迁徙的时间高峰一致。所有物种均受到感染，但只有林鸭（Aix sponsa）和笑鸥表现出疾病或死亡。口咽拭子的病毒滴度高于泄殖腔拭子。病毒脱落的持续时间（1-10天）随临床疾病的严重程度而增加。血凝抑制（HI）和琼脂凝胶前凝集素（AGP）测试均能够检测存活的木鸭和笑鸥中的接种后抗体。 ;在其余4种物种中，HItest比AGP更敏感

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