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首页> 外文期刊>Emerging Infectious Diseases >Lineage 2 West Nile Virus as Cause of Fatal Neurologic Disease in Horses, South Africa
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Lineage 2 West Nile Virus as Cause of Fatal Neurologic Disease in Horses, South Africa

机译：谱系2西尼罗河病毒是导致南非致命性神经疾病的原因

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Serologic evidence suggests that West Nile virus (WNV) is widely distributed in horses in southern Africa. However, because few neurologic cases have been report-ed, endemic lineage 2 strains were postulated to be non-pathogenic in horses. Recent evidence suggests that highly neuroinvasive lineage 2 strains exist in humans and mice. To determine whether neurologic cases are being missed in southern Africa, we tested 80 serum or brain specimens from horses with unexplained fever (n = 48) and/or neu-rologic signs (n = 32) for WNV. From March 2007 through June 2008, using reverse transcription–PCR (RT-PCR) and immunoglobulin (Ig) M ELISA, we found WNV RNA or IgM in 7/32 horses with acute neurologic disease; 5 horses died or were euthanized. In 5/7 horses, no other pathogen was detected. DNA sequencing for all 5 RT-PCR–positive cases showed the virus belonged to lineage 2. WNV lineage 2 may cause neurologic disease in horses in southern Africa
机译：血清学证据表明，西尼罗河病毒（WNV）广泛分布于南部非洲的马匹中。但是，由于很少有神经系统疾病的报道，因此推测流行谱系2株在马中无致病性。最近的证据表明，人类和小鼠中存在高度神经侵袭谱系2株。为了确定南部非洲是否缺少神经系统疾病，我们测试了80例不明原因发热（n = 48）和/或神经系统体征（n = 32）的马的WNV血清或脑标本。从2007年3月到2008年6月，我们使用逆转录PCR（RT-PCR）和免疫球蛋白（Ig）M ELISA在7/32例患有急性神经系统疾病的马中发现了WNV RNA或IgM。 5匹马死亡或被安乐死。在5/7匹马中，未检测到其他病原体。所有5个RT-PCR阳性病例的DNA测序均表明该病毒属于谱系2。WNV谱系2可能导致南部非洲马匹的神经系统疾病

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