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首页> 外文期刊>Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation >Population Genetics and Molecular Evolution of DNA Sequences in Transposable Elements. I. A Simulation Framework
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Population Genetics and Molecular Evolution of DNA Sequences in Transposable Elements. I. A Simulation Framework

机译：转座因子中DNA序列的种群遗传学和分子进化。一，仿真框架

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A population genetic simulation framework is developed to understand the behavior and molecular evolution of DNA sequences of transposable elements. Our model incorporates random transposition and excision of transposable element (TE) copies, two modes of selection against TEs, and degeneration of transpositional activity by point mutations. We first investigated the relationships between the behavior of the copy number of TEs and these parameters. Our results show that when selection is weak, the genome can maintain a relatively large number of TEs, but most of them are less active. In contrast, with strong selection, the genome can maintain only a limited number of TEs but the proportion of active copies is large. In such a case, there could be substantial fluctuations of the copy number over generations. We also explored how DNA sequences of TEs evolve through the simulations. In general, active copies form clusters around the original sequence, while less active copies have long branches specific to themselves, exhibiting a star-shaped phylogeny. It is demonstrated that the phylogeny of TE sequences could be informative to understand the dynamics of TE evolution.
机译：开发了种群遗传模拟框架，以了解可转座因子DNA序列的行为和分子进化。我们的模型包括随机转座和可转座元件（TE）副本的切除，针对TE的两种选择模式以及点突变导致的转座活性退化。我们首先研究了TE拷贝数的行为与这些参数之间的关系。我们的研究结果表明，当选择较弱，基因组可以保持一个相对大量的跨国企业，但大部分都是不太活跃。相反，通过强选择，基因组只能维持有限数量的TE，但是活性拷贝的比例却很大。在这种情况下，副本数量可能会在几代人之间有很大的波动。我们还探讨了TEs的DNA序列如何通过模拟进化。通常，活性拷贝在原始序列周围形成簇，而活性较低的拷贝具有特异于其自身的长分支，表现出星形系统发育。结果表明，TE序列的系统发育可能有助于理解TE进化的动力学。

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