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首页> 外文期刊>E3S Web of Conferences >Exogenous damage causes cell DNA damage through mediated reactive oxygen levels
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Exogenous damage causes cell DNA damage through mediated reactive oxygen levels

机译：外源性损伤通过介导的活性氧水平引起细胞DNA损伤

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摘要

Many anti-tumor drugs can induce tumor apoptosis by increasing intracellular ROS. In the present study, we build a model which did not directly cause DNA damage, but simulated damage products. The model of this injury was transferred into the cell so that the cell’s damage recognition mechanism mistakenly recognized that its own DNA was damaged, which in turn induced a response. Based on this model, the damaged plasmids (exogenous DNA damage) were transferred into the cells and the amount of reactive oxygen in the cells was improved, and DNA damage of the cells was increased. Therefore, exogenous DNA damage can affect the accumulation of damage in cells by affecting the level of reactive oxygen species, which provides a reference for DNA damage repair research.
机译：许多抗肿瘤药物可以通过增加细胞内ROS来诱导肿瘤凋亡。在本研究中，我们建立了一个模型，该模型不会直接造成DNA损伤，而是模拟损伤产物。这种损伤的模型被转移到细胞中，因此细胞的损伤识别机制错误地识别出其自身的DNA被破坏，从而引起了反应。基于该模型，将受损的质粒（外源DNA损伤）转移到细胞中，提高了细胞中活性氧的量，并增加了细胞的DNA损伤。因此，外源性DNA损伤可通过影响活性氧水平来影响细胞中损伤的积累，为DNA损伤修复研究提供参考。

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