Activation of c-myc and c-K-ras oncogenes in primary rat tumors induced by ionizing radiation.

M J Sawey; A T Hood; F J Burns; S J Garte

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Activation of c-myc and c-K-ras oncogenes in primary rat tumors induced by ionizing radiation.

机译：电离辐射诱导的原发性大鼠肿瘤中c-myc和c-K-ras癌基因的激活。

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An activated K-ras oncogene was detected by transfection in NIH 3T3 cells and by Southern blot analysis in 6 of 12 rat skin tumors induced by ionizing radiation. The DNA from 10 of the 12 tumors also showed c-myc gene amplification and restriction polymorphisms. Evidence for tissue specificity was observed in patterns of oncogene activation, with each of three clear cell carcinomas exhibiting activation of both c-myc and K-ras oncogenes.

机译：通过在NIH 3T3细胞中转染并通过Southern blot分析在电离辐射诱导的12只大鼠皮肤肿瘤中的6种中检测到了活化的K-ras癌基因。 12种肿瘤中10种的DNA也显示c-myc基因扩增和限制性多态性。在癌基因激活模式中观察到组织特异性的证据，三种透明细胞癌均表现出c-myc和K-ras癌基因的激活。

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《Molecular and Cellular Biology》 |1987年第2期|共4页
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M J Sawey; A T Hood; F J Burns; S J Garte;
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中图分类细胞生物学;
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1. Activation of c-myc and c-K-ras oncogenes in primary rat tumors induced by ionizing radiation. [J] . M J Sawey, A T Hood, F J Burns, Molecular and Cellular Biology . 1987,第2期

机译：电离辐射诱导的原发性大鼠肿瘤中c-myc和c-K-ras癌基因的激活。
2. Activated K-ras and N-ras oncogenes in primary renal mesenchymal tumors induced in F344 rats by methyl(methoxymethyl)nitrosamine. [J] . S Sukumar, A Perantoni, C Reed, Molecular and Cellular Biology . 1986,第7期

机译：甲基（甲氧基甲基）亚硝胺诱导的F344大鼠原发性肾间质肿瘤中活化的K-ras和N-ras癌基因。
3. Activated K-ras and N-ras oncogenes in primary renal mesenchymal tumors induced in F344 rats by methyl(methoxymethyl)nitrosamine. [J] . S Sukumar, A Perantoni, C Reed, Molecular and Cellular Biology . 1986,第7期

机译：甲基（甲氧基甲基）亚硝胺诱导的F344大鼠原发性肾间质肿瘤中活化的K-ras和N-ras癌基因。
4. Desorption Electrospray Ionization Imaging: Identification of Lipid Species Regulated by the c-MYC Oncogene [C] . Ali I. Ismail, Richard H. Perry, Emelyn H. Shroff, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：解吸电喷雾电离成像：鉴定C-MYC癌基因调节的脂质物种
5. Studies on proto-oncogene function: The roles of c-MYC and Akt1 in mammary development and tumorigenesis. [D] . Boxer, Robert B. 2004

机译：原癌基因功能研究：c-MYC和Akt1在乳腺发育和肿瘤发生中的作用。
6. Activation of c-myc and c-K-ras oncogenes in primary rat tumors induced by ionizing radiation. [O] . M J Sawey, A T Hood, F J Burns, 1987

机译：电离辐射诱导的原发性大鼠肿瘤中c-myc和c-K-ras癌基因的激活。
7. Activation of c-myc and c-K-ras oncogenes in primary rat tumors induced by ionizing radiation. [O] . Sawey, M J, Hood, A T, Burns, F J, 1987

机译：电离辐射诱导的原发性大鼠肿瘤中c-myc和c-K-ras癌基因的激活。

Activation of c-myc and c-K-ras oncogenes in primary rat tumors induced by ionizing radiation.

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