Correlation between phosphorylation of a 34,000-molecular-weight protein, pp60src-associated kinase activity, and tumorigenicity in transformed and revertant vole cells.

J F Nawrocki; A F Lau; A J Faras

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Correlation between phosphorylation of a 34,000-molecular-weight protein, pp60src-associated kinase activity, and tumorigenicity in transformed and revertant vole cells.

机译：34,000分子量蛋白质的磷酸化，与pp60src相关的激酶活性与转化和回复田鼠细胞中致瘤性之间的相关性。

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The phosphorylation of a 34,000-molecular-weight (34K) cell protein, purported to be a substrate of the avian retrovirus pp60src-associated protein kinase activity, was compared in three types of Rous sarcoma virus-infected vole cells: fully transformed cells, partial revertants which are morphologically normal in appearance but retain their tumorigenic potential, and full revertants which are similar to normal vole cells in all parameters including a lack of tumorigenicity. Although similar amounts of 34K protein are present in all three cell types, phosphorylation of the 34K protein was significantly reduced in the full revertant cell type. The reduced phosphorylation occurred at the tyrosine residue.

机译：在三种经劳斯肉瘤病毒感染的田鼠细胞中比较了一种34,000分子量（34K）细胞蛋白的磷酸化作用，该蛋白据称是禽逆转录病毒pp60src相关蛋白激酶活性的底物。在形态上是正常的但仍保留其致瘤潜力的逆转株，以及在包括致瘤性缺乏在内的所有参数上均与正常田鼠细胞相似的完全逆转株。尽管在所有三种细胞类型中都存在相似数量的34K蛋白，但在完全回复细胞类型中34K蛋白的磷酸化作用显着降低。磷酸化的减少发生在酪氨酸残基上。

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《Molecular and Cellular Biology》 |1984年第1期|共4页
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J F Nawrocki; A F Lau; A J Faras;
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中图分类细胞生物学;
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1. 94,000- and 100,000-molecular-weight simian virus 40 T-antigens are associated with the nuclear matrix in transformed and revertant mouse cells. [J] . M F Verderame, D S Kohtz, R E Pollack Journal of Virology . 1983,第2期

机译：94,000-100,000分子量的Simian病毒40 T-抗原与转化和倒剂小鼠细胞中的核基质相关。
2. 94,000- and 100,000-molecular-weight simian virus 40 T-antigens are associated with the nuclear matrix in transformed and revertant mouse cells. [J] . M F Verderame, D S Kohtz, R E Pollack Journal of Virology . 1983,第2期

机译：94,000-100,000分子量的Simian病毒40 T-抗原与转化和倒剂小鼠细胞中的核基质相关。
3. 94,000- and 100,000-molecular-weight simian virus 40 T-antigens are associated with the nuclear matrix in transformed and revertant mouse cells. [J] . M F Verderame, D S Kohtz, R E Pollack Journal of Virology . 1983,第2期

机译：94,000-100,000分子量的Simian病毒40 T-抗原与转化和倒剂小鼠细胞中的核基质相关。
4. REGULATION OF PROTEIN PHOSPHORYLATION AT THE POSTSYNAPTIC DENSITY- GLOBAL ANALYSIS TARGETING SPECIFIC KINASE AND PHOSPHATASE ACTIVITIES [C] . Howard Jaffe, Ayse Dosemeci American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：在突触后密度 - 全局分析靶向靶向特异性激酶和磷酸酶活性的调节
5. Investigation of Inducible Mitogen and Stress Activated Protein Kinase 1 (MSK1) and Histone H3 Phosphorylation by the RAS-MAPK Pathway in Cancer Cells. [D] . Espino, Paula. 2010

机译：通过癌细胞中的RAS-MAPK途径研究诱导型丝裂原和应激激活的蛋白激酶1（MSK1）和组蛋白H3磷酸化。
6. Correlation between phosphorylation of a 34000-molecular-weight protein pp60src-associated kinase activity and tumorigenicity in transformed and revertant vole cells. [O] . J F Nawrocki, A F Lau, A J Faras 1984

机译：34000分子量蛋白的磷酸化与pp60src相关的激酶活性与转化和回复田鼠细胞中致瘤性之间的相关性。
7. Correlation between phosphorylation of a 34,000-molecular-weight protein, pp60src-associated kinase activity, and tumorigenicity in transformed and revertant vole cells. [O] . Nawrocki, J F, Lau, A F, Faras, A J 1984

机译：34,000分子量蛋白的磷酸化，与pp60src相关的激酶活性与转化和回复田鼠细胞中致瘤性之间的相关性。
8. Protein Kinase C Activity and Substrate (F1/GAP-43) Phosphorylation in DevelopingCat Visual Cortex [R] . Sheu, F. S., Kasamatsu, T., Routtenberg, A. 1990

机译：蛋白激酶C活性和底物（F1 / Gap-43）磷酸化在DevelopingCat视觉皮层

Correlation between phosphorylation of a 34,000-molecular-weight protein, pp60src-associated kinase activity, and tumorigenicity in transformed and revertant vole cells.

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