Specific activation of the cellular Harvey-ras oncogene in dimethylbenzanthracene-induced mouse mammary tumors.

S Dandekar; S Sukumar; H Zarbl; L J Young; R D Cardiff

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Specific activation of the cellular Harvey-ras oncogene in dimethylbenzanthracene-induced mouse mammary tumors.

机译：在二甲基苯并蒽诱导的小鼠乳腺肿瘤中细胞Harvey-ras癌基因的特异性激活。

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Genomic DNAs from dimethylbenzanthracene-induced BALB/c mouse mammary tumors arising from the transplantable hyperplastic outgrowth (HPO) line designated DI/UCD transformed NIH 3T3 cells upon transfection. Transforming activity was attributed to the presence of activated Harvey ras-1 oncogenes containing an A----T transversion at the middle adenosine nucleotide in codon 61. DNAs from untreated DI/UCD HPO cells and radiation-induced and spontaneous mammary tumors from the DI/UCD HPO line failed to transform NIH 3T3 cells. The results indicated that the mutation activation of Harvey ras-1 oncogenes was specific to dimethylbenzanthracene treatment in the mouse mammary tumor system.

机译：来自二甲基苯并蒽诱导的BALB / c小鼠乳腺肿瘤的基因组DNA，是由转染后称为DI / UCD的可移植的增生性增生（HPO）系转化而成的NIH 3T3细胞。转化活性归因于激活的Harvey ras-1癌基因的存在，该基因在61号密码子的中间腺苷核苷酸处含有A ---- T转换。 DI / UCD HPO品系未能转化NIH 3T3细胞。结果表明，Harvey ras-1癌基因的突变激活对小鼠乳腺肿瘤系统中的二甲基苯并蒽具有特异性。

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《Molecular and Cellular Biology》 |1986年第11期|共5页
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S Dandekar; S Sukumar; H Zarbl; L J Young; R D Cardiff;
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中图分类细胞生物学;
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1. Specific activation of the cellular Harvey-ras oncogene in dimethylbenzanthracene-induced mouse mammary tumors. [J] . S Dandekar, S Sukumar, H Zarbl, Molecular and Cellular Biology . 1986,第11期

机译：在二甲基苯并蒽诱导的小鼠乳腺肿瘤中细胞Harvey-ras癌基因的特异性激活。
2. Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors. [J] . P M Siegel, D L Dankort, W R Hardy, Molecular and Cellular Biology . 1994,第11期

机译：神经元原癌基因中的新型激活突变参与了乳腺肿瘤的诱导。
3. A mammary cell-specific enhancer in mouse mammary tumor virus DNA is composed of multiple regulatory elements including binding sites for CTF/NFI and a novel transcription factor, mammary cell-activating factor. [J] . S Mink, E H?rtig, P Jennewein, Molecular and Cellular Biology . 1992,第11期

机译：小鼠乳腺肿瘤病毒DNA中的乳腺细胞特异性增强剂由多种调控元件组成，包括CTF / NFI的结合位点和新型转录因子乳腺细胞激活因子。
4. Lipidomic Classification of Human Mammary Cancer Cells According to Metastatic Potential and Oncogene Expression by Desorption Electrospray Ionization Mass Spectrometry [C] . Heather M. Robison, Troy J. Comi, Seung W. Ryu, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

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5. Dissecting the mechanisms of CD8+ T cell tolerance to the proto-oncogene HER-2/NEU in the HER-2/NEU transgenic mouse model of mammary cancer. [D] . Ercolini, Anne Marisa. 2003

机译：在乳腺癌的HER-2 / NEU转基因小鼠模型中剖析CD8 + T细胞对原癌基因HER-2 / NEU的耐受性机制。
6. Specific activation of the cellular Harvey-ras oncogene in dimethylbenzanthracene-induced mouse mammary tumors. [O] . S Dandekar, S Sukumar, H Zarbl, 1986

机译：在二甲基苯并蒽诱导的小鼠乳腺肿瘤中细胞Harvey-ras癌基因的特异性激活。
7. Specific activation of the cellular Harvey-ras oncogene in dimethylbenzanthracene-induced mouse mammary tumors. [O] . Dandekar, S, Sukumar, S, Zarbl, H, 1986

机译：在二甲基苯并蒽诱导的小鼠乳腺肿瘤中细胞Harvey-ras癌基因的特异性激活。
8. Developing a Novel Mouse Model for Breast Cancer by Targeting Oncogenes to Mammary Progenitor Cells. [R] . Li, Y. 2005

机译：通过将致癌基因靶向乳腺祖细胞开发新的乳腺癌小鼠模型。

Specific activation of the cellular Harvey-ras oncogene in dimethylbenzanthracene-induced mouse mammary tumors.

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