Position effects on the timing of replication of chromosomally integrated simian virus 40 molecules in Chinese hamster cells.

D M Gilbert; S N Cohen

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Position effects on the timing of replication of chromosomally integrated simian virus 40 molecules in Chinese hamster cells.

机译：位置对中国仓鼠细胞中染色体整合的猿猴病毒40分子复制时间的影响。

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Simian virus 40 (SV40) DNA molecules chromosomally integrated at different sites in three Chinese hamster lung fibroblast lines replicated during the middle portion of S phase but not precisely at the same time in all three cell lines. The time of replication was unrelated to the presence of T antigen or to its relative activity in promoting SV40 replication. SV40 sequences and chromosomal DNA sequences adjacent to the SV40 insert in one cell line expressing a temperature-sensitive T antigen showed a T-antigen-independent difference in replication timing from the homologous, allelic locus not linked to SV40. Our results indicate that the timing of replication of these integrated SV40 molecules is dependent upon the site of integration and is not determined by the level of T antigen replication-promoting activity.

机译：在S期中段复制的三个中国仓鼠肺成纤维细胞系的不同位点，染色体整合了猿猴病毒40（SV40）DNA分子，但在所有这三个细胞系中并非精确地同时复制。复制的时间与T抗原的存在或其在促进SV40复制中的相对活性无关。在一个表达温度敏感性T抗原的细胞系中，与SV40插入片段相邻的SV40序列和染色体DNA序列与不与SV40连接的同源等位基因座在复制时间上显示出T抗原独立性差异。我们的结果表明，这些整合的SV40分子复制的时机取决于整合的位置，而不是由T抗原复制促进活性的水平决定的。

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《Molecular and Cellular Biology》 |1990年第8期|共11页
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D M Gilbert; S N Cohen;
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中图分类细胞生物学;
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1. Simian virus 40-Chinese hamster kidney cell interaction. V. Cooperative effect of 5-iodo-2'-deoxyuridine and mitomycin C in the enhancement of virus replication in infected cells. [J] . H G Suárez, C Lavialle, R Cassingena Journal of Virology . 1980,第1期

机译：Simian病毒40-中国仓鼠肾细胞相互作用。 V. 5-Iodo-2'-脱氧尿苷和丝裂霉素C在感染细胞中病毒复制中的合作效应。
2. Simian virus 40-Chinese hamster kidney cell interaction. V. Cooperative effect of 5-iodo-2'-deoxyuridine and mitomycin C in the enhancement of virus replication in infected cells. [J] . H G Suárez, C Lavialle, R Cassingena Journal of Virology . 1980,第1期

机译：Simian病毒40-中国仓鼠肾细胞相互作用。 V. 5-Iodo-2'-脱氧尿苷和丝裂霉素C在感染细胞中病毒复制中的合作效应。
3. Simian virus 40-Chinese hamster kidney cell interaction. V. Cooperative effect of 5-iodo-2'-deoxyuridine and mitomycin C in the enhancement of virus replication in infected cells. [J] . H G Suárez, C Lavialle, R Cassingena Journal of Virology . 1980,第1期

机译：Simian病毒40-中国仓鼠肾细胞相互作用。 V. 5-Iodo-2'-脱氧尿苷和丝裂霉素C在感染细胞中病毒复制中的合作效应。
4. Computational Analysis of Nucleosome Positioning Signals in the Simian Virus 40 Chromatin [C] . Hongyan Zhao, Hong Yan International MultiConference of Engineers and Computer Scientists . 2009

机译：亚麻病毒40染色质中核心定位信号的计算分析
5. Using simian virus 40 as a model to determine the effects of replication and transcription on histone methylation. [D] . Kallestad, Les. 2016

机译：使用猿猴病毒40作为模型来确定复制和转录对组蛋白甲基化的影响。
6. Position effects on the timing of replication of chromosomally integrated simian virus 40 molecules in Chinese hamster cells. [O] . D M Gilbert, S N Cohen 1990

机译：位置对中国仓鼠细胞中染色体整合的猿猴病毒40分子复制时间的影响。
7. Position effects on the timing of replication of chromosomally integrated simian virus 40 molecules in Chinese hamster cells. [O] . Gilbert, D M, Cohen, S N 1990

机译：位置对中国仓鼠细胞中染色体整合的猿猴病毒40分子复制时间的影响。
8. In Vitro Chromosome Aberration Study Performed on the Huntsman Product FAT 40'162/B Reported a Clastogenic Effect on Cultured Chinese Hamster V79 Cells. [R] . 2006

机译：在亨斯迈产品FaT 40'162 / B上进行的体外染色体畸变研究报道了对培养的中国仓鼠V79细胞的致裂作用。

Position effects on the timing of replication of chromosomally integrated simian virus 40 molecules in Chinese hamster cells.

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