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The Saccharomyces cerevisiae genome contains functional and nonfunctional copies of transposon Ty1.

机译:酿酒酵母基因组包含转座子Ty1的功能和非功能副本。

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Saccharomyces cerevisiae Ty elements are transposons closely related to retroviruses. The DNA sequence of a functional Ty element (TyH3) is presented. The long terminal repeat sequences are different, suggesting that TyH3 is a recombinant Ty element. A chromosomal Ty element near the LYS2 gene, Ty173, was found to be nonfunctional, even though it has no detectable insertions or deletions. The defect in Ty173 transposition is caused by a missense mutation giving rise to a Leu-to-Ile substitution in the TYB (pol) open reading frame. Several chromosomal Ty elements carry this lesion in their DNA, indicating that nonfunctional Ty elements are common in the yeast genome.
机译:酿酒酵母Ty元件是与逆转录病毒密切相关的转座子。给出了功能性Ty元素(TyH3)的DNA序列。长的末端重复序列是不同的,表明TyH3是重组Ty元件。发现LYS2基因附近的染色体Ty元件Ty173不起作用,即使它没有可检测到的插入或缺失。 Ty173转座的缺陷是由一个错义突变引起的,该突变导致在TYB(pol)开放阅读框中的Leu-Ile取代。几种染色体上的Ty元素在其DNA中携带该病灶,表明在酵母基因组中常见的无功能Ty元素。

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