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首页> 外文期刊>Molecular and Cellular Biology >Transcription of the chicken histone H5 gene is mediated by distinct tissue-specific elements within the promoter and the 3' enhancer.
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Transcription of the chicken histone H5 gene is mediated by distinct tissue-specific elements within the promoter and the 3' enhancer.

机译：鸡组蛋白H5基因的转录是由启动子和3'增强子中不同的组织特异性元件介导的。

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摘要

Molecular genetic analysis of a number of vertebrate erythroid cell-specific genes has identified at least two types of cis-acting regulatory sequences which control the complex developmental pattern of gene expression during erythroid cell maturation. Tissue-specific cellular enhancers have been identified 3' to three erythroid cell-specific genes, and additional regulatory elements have been identified in the promoters of many erythroid genes. We show that the histone H5 enhancer, like the adult beta-globin enhancer, is involved in mediating the developmental induction of histone H5 mRNA as erythroid cells mature. We also describe the preliminary characterization of a tissue-specific regulatory element within the 5' region of the H5 locus and describe investigations of the interaction between this element and the histone H5 enhancer in mediating histone H5 regulation.
机译：对许多脊椎动物类红细胞特异性基因的分子遗传学分析已经确定了至少两种类型的顺式调节序列，它们控制着类红细胞成熟过程中基因表达的复杂发育模式。组织特异性细胞增强剂已被鉴定为三个类红细胞特异性基因的3'端，并且在许多类红细胞基因的启动子中还发现了其他调控元件。我们显示，组蛋白H5增强剂，像成人的β-珠蛋白增强剂一样，在红细胞成熟时参与介导组蛋白H5 mRNA的发育诱导。我们还描述了H5基因座5'区域内的组织特异性调控元件的初步表征，并描述了在介导组蛋白H5调控中该元件与组蛋白H5增强子之间相互作用的研究。

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