Inhibition of histone H2B gene transcription and of cellular growth by a truncated viral trans-activator protein.

C L Dent; J K Estridge; L M Kemp; D S Latchman

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Inhibition of histone H2B gene transcription and of cellular growth by a truncated viral trans-activator protein.

机译：截短的病毒反式激活蛋白抑制组蛋白H2B基因转录和细胞生长。

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The herpes simplex virus virion protein Vmw65 trans activates the viral immediate-early genes and some octamer-containing cellular genes, including that encoding histone H2B. We found, however, that a truncated form of this virion protein repressed H2B gene transcription and also dominantly inhibited induction of the gene by intact Vmw65. A cell line expressing this truncated protein expressed reduced levels of H2B and grew more slowly than the parental cell line or a similar line expressing the intact protein.

机译：单纯疱疹病毒毒粒蛋白Vmw65反式激活病毒的早期基因和一些包含八聚体的细胞基因，包括编码组蛋白H2B的细胞基因。但是，我们发现该病毒体蛋白的截短形式抑制了H2B基因的转录，并且还主要抑制了完整Vmw65对基因的诱导。表达这种截短蛋白的细胞系表达的H2B水平降低，并且比亲本细胞系或表达完整蛋白的类似系生长得更慢。

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《Molecular and Cellular Biology》 |1990年第6期|共4页
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C L Dent; J K Estridge; L M Kemp; D S Latchman;
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中图分类细胞生物学;
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1. The different competitive abilities of viral TAATGARAT elements and cellular octamer motifs, mediate the induction of viral immediate-early genes and the repression of the histone H2B gene in herpes simplex virus infected cells [J] . D.S. Latchman, J.F. Pratridge, L.M. Kemp Nucleic acids research . 1989,第21期

机译：病毒TAATGARAT元件和细胞八聚体基序的不同竞争能力介导单纯疱疹病毒感染细胞中病毒即早基因的诱导和组蛋白H2B基因的阻遏
2. Interactive and noninteractive roles of histone H2B monoubiquitination and H3K36 methylation in the regulation of active gene transcription and control of plant growth and development [J] . Zhao Wei, Neyt Pia, Van Lijsebettens Mieke, The New Phytologist . 2019,第2期

机译：组织H2B单体化和H3K36甲基化在激活基因转录调节中的互动和非互连作用及植物生长发育中的控制
3. Stabilization of SIRT7 deacetylase by viral oncoprotein HBx leads to inhibition of growth restrictive RPS7 gene and facilitates cellular transformation [J] . Vijaya Pandey, Vijay Kumar Scientific reports. . 2015,第1期

机译：病毒癌蛋白HBx稳定SIRT7脱乙酰基酶可抑制生长限制性 RPS7 基因并促进细胞转化
4. Modulation of Cellular Behavior by Inhibition of Intracellular Enzymes to Enhance in vitro Transient Non‐Viral Polymer‐Mediated Transgene Expression [C] . Matthew Christensen, Jacob Elmer, Sutapa Barua AIChE Annual Meeting . 2014

机译：通过抑制细胞内酶来增强体外瞬时非病毒聚合物介导的转基因表达的调节
5. Regulation of gene transcription by the histone H2A and H2B N -terminal domains [D] . Parra, Michael Anthony 2007

机译：通过组蛋白H2A和H2B N末端域对基因转录的调控
6. Inhibition of histone H2B gene transcription and of cellular growth by a truncated viral trans-activator protein. [O] . C L Dent, J K Estridge, L M Kemp, 1990

机译：截短的病毒反式激活蛋白抑制组蛋白H2B基因转录和细胞生长。
7. Inhibition of histone H2B gene transcription and of cellular growth by a truncated viral trans-activator protein. [O] . Dent, C L, Estridge, J K, Kemp, L M, 1990

机译：截短的病毒反式激活蛋白抑制组蛋白H2B基因转录和细胞生长。

Inhibition of histone H2B gene transcription and of cellular growth by a truncated viral trans-activator protein.

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